芩榆烧伤液治疗烧烫伤的主要药效学研究  

Pharmacodynamical Investigation on Qinyu Burn Liquid for Treatment of Burn and Scald Healing

作　　者：张晗[1] 杨巧丽 李寅[3] 李维强[1] 刘循[3] 

机构地区：[1]中国人民解放军69220部队医院 [2]新疆维吾尔自治区药物研究所 [3]新疆石河子大学药学院

出　　处：《中国实验方剂学杂志》2011年第15期152-156,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：新疆维吾尔自治区科技基础条件平台建设项目(PT1008)

摘　　要：目的:探讨芩榆烧伤液对烧烫伤的治疗作用。方法:采用大鼠深Ⅱ度烫伤模型进行烫伤实验,采用二甲苯致小鼠皮肤毛细血管通透性增高法和二甲苯致小鼠耳肿胀法进行抗炎实验,采用醋酸扭体法和小鼠热板法进行镇痛实验,采用肉汤稀释法测定芩榆烧伤液的最低抑菌浓度(MIC)、最低杀菌浓度(MBC),对芩榆烧伤液进行烧烫伤、抗炎、镇痛、体外抑菌的实验。结果:芩榆烧伤液2个剂量(按生药量计0.25 g,0.50 g.mL-1,0.18 mL/次,每日喷2～3次)对大鼠深Ⅱ度烫伤创面愈合有较好的促进作用,芩榆烧伤液2个剂量(每只20μL×4次,每次间隔30～60 min)对二甲苯致小鼠皮肤毛细血管通透性增高和小鼠耳肿胀均有显著的抑制作用,对醋酸致小鼠扭体和小鼠热板致痛有显著的抑制作用,对金黄色葡萄球菌、绿脓杆菌和大肠杆菌的MIC分别为1.95,7.80,15.60 g.L-1,MBC分别为7.80,15.60,31.25 g.L-1。结论:芩榆烧伤液具有促进大鼠深Ⅱ度烫伤模型创面愈合、镇痛、抗炎作用,在体外对金黄色葡萄球菌、绿脓杆菌和大肠杆菌均有一定的抑菌作用。Objective：To investigate effect of Qinyu Burn Liquid（QY） for treatment of burn and scald healing.Method：The burn and scald healing effect of the QY was studied with the scald model of deep Ⅱ degree in rats.Anti-inflammatory effect of the QY was studied with the model of mouse with increase in skinny capillary permeability and the ear swelling induced by xylol in mouse.And,analgesic effect of QY was studied with mouse writhing response and hot plate test.The minimal inhibitory concentration（MIC） and minimal bactericidal concentration（MBC） of QY were determinand by broth dilution method.Result：QY of two doses（crude drugs 0.25 g,0.50 g·mL-1,0.18 mL/times,spray 2 to 3 times a day） had promoting role on rat burn wound healing deepⅡ.QY of two doses（each 20 μL × 4 times,each times interval of 30-60 min） could also obviously inhibit the increase of skin capillaries permeability and swelling of ear in mice induced by xylene,could significantly inhibit twisting caused by acetic acid and pain induced by hot plate in mice,and MIC were respectively 1.95,7.80,15.60 g·L-1 and the MBC were 7.80,15.60,31.25 g·L-1 to Staphylococcus aureus,Pseudomonas aeruginosa and Escherchia coli（E.coli）.Conclusion：On one hand the wound heal time of QY for rats with Ⅱ degree deep scald is superior to that of the model group.On the other hand,QY also has significant analgesic,anti-inflammatory and effect on S.aureus,P.aeruginosa and E.coli,especially S.aureus.

关 键 词：芩榆烧伤液 烧烫伤 镇痛 抗炎 抑菌 

分 类 号：R285.5[医药卫生—中药学]