不同色泽紫石英镇静催眠抗惊厥作用的研究  

Experimental Study on Sedation,Syngignoscism and Anticonvulsant Actions of Fluoritum with Different Colour

作　　者：王怡薇[1] 朱传静[1] 王彦礼[1] 康琛[1] 李涛[1] 杨伟鹏[1] 李曼玲[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2011年第15期199-201,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"十一五"科技支撑项目(2006BAI55B02)

摘　　要：目的:考察不同色泽紫石英的镇静催眠抗惊厥作用。方法:以小鼠的急性毒性试验考察不同色泽紫石英23#,25#,29#的急性毒性,以小鼠自主活动、睡眠时间及戊四氮引起的惊厥试验考察不同色泽紫石英20 g.kg-1,连续ig 3 d的镇静催眠抗惊厥作用。结果:不同色泽紫石英对小鼠未见急性毒性反应,不同色泽紫石英小鼠自主活动次数均有所减少,但无显著性差异,不同色泽紫石英都能明显延长戊巴比妥钠阈剂量小鼠的睡眠时间,与戊巴比妥钠具有协同作用,其中23#,25#有显著性差异(P<0.05或P<0.01),不同色泽紫石英对小鼠惊厥发作数没有明显影响,惊厥潜伏时间未有延长。结论:紫石英对小鼠没有明显毒性反应,可减少小鼠自主活动次数、延长戊巴比妥钠小鼠睡眠时间,与戊巴比妥钠具有协同作用,对惊厥发作数和惊厥潜伏时间没有明显影响。紫石英具有一定的镇静安神的作用,不同色泽紫石英在药效方面没有显著性差异。Objective：To investigate the sedation,syngignoscism and anticonvulsant actions of different Fluoritum with different colour.Method：The acute toxicity of Fluoritum with different colour was investigated by mice acute toxicity test.The sedation,syngignoscism and anticonvulsant actionss of the Fluoritum（20 g·kg^-1,ig,3 d）were evaluated by testing and observing independent activity,sleep time and convulsion caused by pentrazole in mice.Result：It was not seen the acute toxicity in mice treated by Fluoritum with different colour.Mice treated with Fluoritum reduced the time of independent activities without significant difference.All the Fluoritum with different colour could extend the sleep time of mice with threshold dose of pentobarbital sodium obviously,and showed synergistic effect with pentobarbital sodium.Among them,the 23#,25# showed the obvious differences（P〈0.05 or P〈0.01）.Fluoritum with different colour did not influenced the time of convulsion of mice significantly.There were no obvious difference and no extension on the elapsed time of convulsion as well.Conclusion：It is not seen the acute toxicity of mice treated with treated Fluoritum with different colour.Fluoritum can reduce the times of independent activities of mice,and extend the sleep time of mice treated with pentobarbital sodium,there for,has synergistic effect with pentobarbital sodium.It has no obvious impact on both the time and the amount of time of convulsion.So,Fluoritum shows sedative action.Fluoritum with different colour shows no significant diffirence.

关 键 词：紫石英 镇静安神 惊厥 

分 类 号：R285.5[医药卫生—中药学]