微透析技术进行药动学研究的发展趋势及局限性探讨  

Pharmacokinetics Study Thinking about Limitations and Development Rrend of Microdialysis Sampling Technology

作　　者：张英丰[1] 汪小根[2] 吴阳[1] 周莉玲[1] 

机构地区：[1]广州中医药大学,广州510006 [2]广东食品药品职业学院,广州510520

出　　处：《中国实验方剂学杂志》2011年第15期270-273,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(30701097;30672669;30873443);中国博士后基金项目(20070420509);广东省自然科学基金项目(9151052005000003)

摘　　要：根据微透析技术采样原理、方法、特点、国内应用概况及作者自身研究体会结合药动学学科发展,从微透析技术的采样部位、采样对象、使用范围、检测方式及样品浓度校正等方面对其发展趋势进行探讨和展望。根据作者实践,发现微透析采样技术亦具有局限性,进而主要从采样对象的角度探讨了微透析技术进行药动学研究中的局限性及解决办法,认为只要充分把握微透析技术的优势与缺陷、适用性与不足,方可正确设计实验,科学研究,扬长避短,合理选择采样手段,避免走弯路。This article deeply discusses the status of microdialysis technology for pharmacokinetic studies from sampling theory, methods, features, domestic application profiles and author experience combined with pharmacokinetic subject development. The microdialysis technology development trend and prospects of sampling site, sampling object, usage range, detection methods and sample concentration correction method, was explored according to author＇ s own practice. It was found that microdialysis sampling technique also has limitations, and thus the limitations and solutions was discussed mainly from sampling object of microdialysis technique in pharmacokinetic studies to provide a reference for researchers.

关 键 词：微透析技术 药动学研究 发展趋势 局限性 

分 类 号：R283[医药卫生—中药学]