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机构地区:[1]中国科学院化学研究所工程塑料院重点实验室,北京100190 [2]北京积水潭医院北京市创伤骨科研究所,北京100035
出 处:《高分子学报》2011年第8期866-873,共8页Acta Polymerica Sinica
基 金:国家自然科学基金(基金号51003109、51025314、50573085);中国科学院战略性先导科技专项(项目号XDA01030301)资助项目
摘 要:利用改进的双乳液溶剂挥发法制备了多孔聚乳酸(PLA)微球.通过采用具有不同沸点和水溶性的有机溶剂制备得到不同多孔结构的PLA微球.结果发现以二氯甲烷、氯仿和甲苯为溶剂制备的微球具有相似的均匀多孔结构,而以乙酸乙酯制备的微球却具有中空结构和多孔的壳层.通过进一步的实验研究了溶剂种类对于微球多孔结构的影响.结果表明溶剂的移出速率对于微球的多孔结构起到决定作用.最后在以上实验基础上探讨了以不同溶剂制备多孔微球的形成机理.Porous polylactide(PLA) microspheres were prepared by means of the modified double emulsion solvent evaporation.The organic solvents with different boiling points and aqueous solubility were used to prepare PLA microspheres with different porous structures.Microspheres prepared with methylene chloride,chloroform and toluene as solvents had the similar homogeneous porous structure,while those microspheres with ethyl acetate as solvent showed a hollow structure with a porous thin shell.The effects of solvent types on porous structure of microspheres were discussed.It was concluded that the removal rate of solvent plays the decisive role in determining the porous structure of microspheres.Accordingly,a formation mechanism of porous microspheres fabricated with different solvents was proposed.
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