对氟苯丙氨酸对约氏疟原虫超微结构的研究  

Ultrastructure Study on the Effects of 4-Fluoro-DL-β- Phenylalanine on the Plasmodium Yoelii

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作  者:卢红[1] 尤力群[2] 陈坚[3] 曹汉民[1] 

机构地区:[1]华东师范大学生物系,上海200062 [2]华东师范大学学报编辑部,上海200062 [3]上海市儿童医院,上海200040

出  处:《华东师范大学学报(自然科学版)》1999年第3期94-98,共5页Journal of East China Normal University(Natural Science)

摘  要:对氟苯丙氨酸(4 - Fluoro- DL- β- Phenylalanine)通常被认为是苯丙氨酸的竞争抑制剂。它对恶性疟原虫的生长有明显的抑制作用。在1 ×10 - 3 mol/L 的用药浓度下,可以有效地损伤约氏原虫( Plasmodium yoelii) 使之在形态结构上出现一系列的变化。主要是膜结构的损伤,此外还有空囊泡的出现和疟色素的变型。Fluoro-DL-β-Phenylalanine, as the competing inhibition of phenylalanine showed a great effect on the growth of Plasmodium yoelii. Under the concentration of 1×10 -3 mol/L, the structure of multilaminal pellicular complex was changed a lot. This work contribute to the knowledge of the 4-Fluoro-DL-β-Phenylalanine's function and the future clinical applicationKey words 4-Fluoro-DL-β-Phenylalanine Plaemodium yoelii ultra structureNG RING CAVITY LASER$$$$ Feng Dejun,Kai Guiyun,Ge Chunfeng,Liu Heliang,Dong Xiaoyi Institute of Modern Optics,Nankai University,Tianjin 300071 Received date:1999-05-25 Abstract The ralationship between output power and output coupling ratio is studied,the experimental results indicate that the optimum output coupling ratio is at about 80%~90%.The output characteristics under different cavity losses are analyzed in theory,and the numerical simulation results are in agreement with the experiments.

关 键 词:对氟苯丙氨酸 约氏疟原虫 超微结构 抗疟药 

分 类 号:R382.31[医药卫生—医学寄生虫学] R978.61[医药卫生—基础医学]

 

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