追赶生长大鼠胃泌素及内脏脂肪细胞CCK2R表达变化  

Changes of serum gastrin and CCK2R expression of visceral adipocytes in catch-up rats

作　　者：黎慧清[1] 陈璐璐[1] 邓秀玲[1] 张皎月[1] 廖云飞[1] 刘振华[1] 宋惠杰[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院内分泌科,武汉430022

出　　处：《中华内分泌代谢杂志》2011年第7期607-609,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：基金项目：国家自然科学基金资助项目（30771035,30800531）

摘　　要：24只Wistar大鼠分为正常对照组、限食组、追赶生长组,检测所有大鼠血糖、血脂、血清胃泌素,内脏脂肪体脂比、脂肪细胞CCK2R mRNA和蛋白水平.结果 显示限食组和正常组相比,血清胃泌素水平降低54%（P＜0.05）,内脏脂肪体脂比减少55%（P＜0.05）,脂肪细胞CCK2R mRNA和蛋白表达下降（2.19±0.18对3.2±0.24,0.11±0.03对0.15±0.04,P＜0.05）.追赶生长组血清胃泌素水平分别高于限食组72%和正常组31%（P＜0.05）,内脏脂肪体脂比高于限食组114%（P＜0.05）,达到正常对照组水平;同时脂肪细胞CCK2R mRNA和蛋白表达高于正常对照组（4.09±0.59对3.2±0.24,0.25±0.05对0.15±0.04,P＜0.05）.追赶生长大鼠内脏脂肪优先沉积的机制可能和胃泌素分泌增加及脂肪细胞CCK2R表达增加相关.Wistar rats（n=24） were divided into normal control group（NC）, food restriction group（FR）, and catch-up group（RN）. Serum glucose,lipids, gastrin, the ratio of visceral fat to body fat, adipocyte CCK2R mRNA and protein levels were determined. Compared with NC group, FR rats had lower serum gastrin and visceral fat formation. The adipocyte CCK2R mRNA and protein levels of FR rats were lower than those of NC rats. Serum gastrin level of RN rats was higher than those of FR and NC rats（P〈0.05）. The ratio of visceral fat to body fat in RN rats increased compared with FR rats and was close to that of NC rats. The adipocyte CCK2R mRNA and protein levels of RN rats were higher than those of FR and NC rats. Gastrin and its receptor pathway possibly play a role in the mechanism of visceral fat accumulation in catch-up rats.

关 键 词：追赶生长 胃泌素 脂肪细胞 CCK2R 

分 类 号：R341[医药卫生—基础医学]