抗磷脂抗体综合征1例  

A Case of Antiphospholipid Syndrome

作　　者：万朋杰[1] 赵肖庆[1] 郑捷[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院皮肤科,上海200025

出　　处：《中国皮肤性病学杂志》2011年第8期634-635,共2页The Chinese Journal of Dermatovenereology

摘　　要：患者女,71岁。6个月前间断出现双下肢紫癜,7d前双小腿出现红斑和坏死,疼痛剧烈,抗心磷脂抗体IgM明显升高,狼疮抗凝物(LAC)和抗β2-糖蛋白I(β2-GPⅠ)均(+),皮损组织病理示:小血管内血栓形成。诊断:抗磷脂抗体综合征。予抗凝治疗3周后患者皮损明显好转。提示临床医师对此类坏死皮损应考虑到本病的可能性,及时予以抗凝治疗。A 71-year old woman presented with a 7-day history of necrotic rash involving both lower limbs. Further questioning revealed that she had been experiencing intermittent purpura, with the first episode occurring o- ver 6 months before. Her anticardiolipin antibody IgM was elevated, lupus anticoagulant and anti-132 glycoprotein-I were both positive. Skin biopsy revealed small vessel thrombi. The diagnosis of antiphospholipid syndrome （APS） was confirmed. Skin lesions have almost completely resolved after three-weeks＇anticoaglulant treatment. It is important for clinicians to recognize this cutaneous sign to promote early diagnosis and anticoagulation.

关 键 词：抗磷脂抗体综合征 坏死 

分 类 号：R593.2[医药卫生—内科学]