腹腔镜胆囊切除术后不同途径给予抗生素对患者疗效的影响  

Effect of Different Administration Route of Antibiotics on Therapeutic Efficacy after Laparoscopic Cholecystectomy

作　　者：冯湧 陈伟[2] 李健开[3] 

机构地区：[1]天津港口医院药剂科,天津市300450 [2]天津港口医院外科,天津市300450 [3]天津港口医院化验室,天津市300450

出　　处：《中国药房》2011年第30期2814-2815,共2页China Pharmacy

摘　　要：目的:评价我院腹腔镜胆囊切除术(LC)后不同途径给予抗生素对患者疗效的影响。方法:选择我院2008-2009年LC患者200例,随机分为A、B组(各100例)。A组术后静脉给予抗生素,B组口服抗生素,均应用3d。通过临床观察、门诊或电话随访,了解患者术后1个月感染性并发症的发生情况,并对术中取得的胆汁进行细菌培养。结果:A组发生感染并发症3例(3%),分别为伤口感染2例、尿路感染1例;B组发生感染并发症4例(4%),均为伤口感染。2组感染率比较差异无统计学意义(P>0.05)。胆汁标本中90例检出细菌,阳性率为45%。所分离细菌以大肠埃希菌为主,其次为产碱假单胞菌。第2代头孢菌素对细菌有较高的敏感率。结论:对成功实施LC的患者,术后应用2种不同给药途径的抗生素不影响其疗效。OBJECTIVE：To evaluate the effect of different administration route of antibiotics on therapeutic efficacies after laparoscopic cholecystectomy （LC） in our hospital.METHODS：200 LC patients in our hospital were selected during 2008-2009 and randomly divided into group A and B,100 patients in each group.Group A was given antibiotics i.v.,and group B was given oral antibiotics for 3 days.After clinical observation,outpatient or telephone interviews were conducted to investigate the incidence of postoperative infectious one month later.The bile of 200 patients were collected,and the germiculture was carried out.RESULTS：3 patients in Group A were infectious complication （3%）,wound infection in 2 patients and urinary tract in one.4 patients in Group B were wound infection.The incidences of postoperative infection were not significantly different between two groups（P0.05）.90 bile samples had a positive result with positive rate of 45%.Major was Escherichia coli,and followed by Pseudomonas alcaligenes.The second generation of cephalosporin had a high sensitive rate to the bacteria.CONCLUSION：For the patients with successful laparoscopic cholecystectomy,no different effect occurs between 2 kinds of administration routes.

关 键 词：腹腔镜胆囊切除术 抗生素 不同给药途径 

分 类 号：R969.3[医药卫生—药理学] R287[医药卫生—药学]