手术方式对创伤性骨折家兔阿片肽含量的影响  

Effect of the mode of operation on β-EP and Met-ENK in rabbits with fracture

作　　者：吴艳琦[1] 李溥[1] 杨广营[2] 黄月娜[2] 

机构地区：[1]黔南民族医学高等专科学校,贵州都匀558001 [2]黔南民族医学高等专科学校第二附属医院,贵州都匀558000

出　　处：《基层医学论坛》2011年第22期688-690,共3页The Medical Forum

摘　　要：目的观察手术方式对创伤性骨折模型家兔血浆β内啡肽(β-EP)及亮氨酸脑啡肽(M et-EN K)含量的影响,探讨手术方式与疼痛的关系。方法选取4个月龄健康新西兰大白兔32只,随机分为克氏针内固定组(A组)、钢板内固定组(B组)、模型组(C组)和正常对照组(D组),分别于手术前、手术后1,3,7,14 d分别抽血采用放射免疫法测定β-EP及M et-EN K的含量。结果①C组随着手术后时间的延长β-EP逐渐下降,与手术前比较有统计学意义(P<0.05);②B组随着手术后时间的延长β-EP及M et-EN K含量均逐渐下降,各时间段分别与手术前比较均有统计学意义(P<0.05);③A组随着手术后时间的延长β-EP及M et-EN K含量均逐渐下降,与手术前比较均有统计学意义(P<0.01),且β-EP及M et-EN K含量水平恢复正常时间较B组短(P<0.01)。结论微创内固定可以影响β-EP及M et-EN K的分泌,可能是通过调节血浆中β-EP及M et-EN K的水平而参与镇痛效应。Objective To study the effect of the mode of operation onβ-endorphin（β-EP） and methionine-enkephalin（Met-ENK）in rabbits with Fracture Operation,and explore its mechanism.Methods 32 health rabbits were randomly divided into four groups： control group,model group,kirschner wires group,steel plate group.Before and after operation for 1,3,7and 14 days,The level of the β-EP and Met-ENK determined by the method of radioimmunity.Results ① The results showed that of theβ-EP decreased significantly of model group（P0.05）.②The results showed that of theβ-EP and Met-ENK decreased significantly of steel plate group（P0.05）.③The results showed that of theβ-EP and Met-ENK decreased significantly of kirschner wires group（P0.01）.The convalescence times were shorter than steel plate group（P0.01）.Conclusion Minimally invasive fixation can affect β-EP and Met-ENK secretion,probably taking part in the analgesic effect by regulating plasma β-EP and Met-ENK levels.

关 键 词：手术方式 疼痛模型 Β内啡肽 亮氨酸脑啡肽 家兔 

分 类 号：R687.3[医药卫生—骨科学]