“海洋甾体”对心肌梗死大鼠心功能的影响及相关机制研究  

The effects of steroid YC-1 on heart function and its underlying mechanism in cardiac infarction rats

作　　者：关信民[1] 蒙荣森[1,2] 陈思伟[1] 裴兆辉[3,4] 邱鹏新 颜光美[4] 

机构地区：[1]广州市红十字会医院心内科,广东广州510220 [2]中山大学附属一院心内科,广东广州510080 [3]南昌市第三医院心内科,江西南昌330009 [4]中山大学中山医学院药理教研室,广东广州510080

出　　处：《中国医药导报》2011年第21期17-19,共3页China Medical Herald

摘　　要：目的:观察海洋甾体(YC-1)对心肌梗死大鼠心功能的影响及相关的机制。方法:将72只SD大鼠随机分为6组,每组12只,即对照组、假手术组、溶剂对照组、心肌梗死组、YC1治疗组、地奥心血康治疗组。观察大鼠血浆NO与内皮素(ET-1)变化,心肌离子型谷氨酸受体(NMDANR1)的表达及大鼠心功能的变化。结果:与心肌梗死组大鼠比较,假手术组与溶剂对照组无明显变化,YC-1治疗组大鼠心功能明显改善,地奥心血康治疗组心功能明善更明显;YC-1治疗组大鼠血浆NO含量显著减少(P<0.01),YC-1治疗组大鼠血浆ET-1含量显著增加(P<0.01),大鼠心功能明显改善(P<0.01);YC-1治疗组大鼠心肌NMDANR1的表达明显减轻(P<0.01)。结论:YC1治疗能够明显减轻心肌梗死大鼠心肌损伤,改善心功能,其作用可能与血浆NO及ET-1含量变化及NMDANR1的表达有关。Objective： To observe the effect of steroid YC-1 on heart function and study its underlying mechanism after acute myocardial infarction in rats.Methods： 72 male Sprague Dawley（SD） rats were randomized into control group（C）,sham operation group（SO）,sham operation＋DMSO group（OD）,LAD occlusion group（LO）,LO＋YC-1 group（LODY）,LO＋Dia group（LODD）,12 rats in a group respectively to measure the changes of NO,ET-1,NMDANR1 and heart function.Results： Compared with the LO group,and the heart function of rats in LODY group was evidently ameliorated（P0.05）,it was more evidently ameliorated（P0.01） in LODD group.The contents of NO in rat plasma were significantly decreased in LODY group（P0.01）,the contents of ET-1 in rat plasma were significantly increased（P0.01） in LODY group,the NMDANR1 expression in rat myocardium was decreased in in LODY group（P0.01）.Conclusion： The heart function of rats can be improved in infarction group after YC-1 treatment,which is relative with the changes of NO,ET-1 and NMDANR1.

关 键 词：海洋甾体 心功能 心肌梗死 改善 

分 类 号：R542.2[医药卫生—心血管疾病]