慢性肾功衰患者骨密度与钙调节激素和胱抑素C的变化和关系  

The relationship among bone mineral density,calcium regulation hormones,and cystatin C in patients with chronic renal failure

作　　者：毛达勇[1] 赵娟[1] 喻飞 李文兵[1] 张吉才[1] 

机构地区：[1]湖北医药学院附属太和医院,十堰442000 [2]湖北省郧西县人民医院

出　　处：《中国骨质疏松杂志》2011年第7期593-595,共3页Chinese Journal of Osteoporosis

摘　　要：目的探讨慢性肾功能衰竭患者的骨密度(bone mineral density,BMD)与钙调节激素和胱抑素C的变化和关系。方法用双能X线吸收测量法(DEXA)检测75例慢性肾功衰患者(简称为CRF组)和50例正常对照组的骨密度(BMD),并测定各自的生化指标:血钙(Ca)、血磷(P)、碱性磷酸酶(ALP)、胱抑素C(Cys C)和钙调节激素指标:甲状旁腺素(PTH)、降钙素(CT)、骨钙素(BGP),做统计分析。结果 CRF组BMD较对照组显著降低(P<0.01);P、ALP、PTH、BGP和CT显著升高(P<0.01),Ca降低(P<0.01)。BMD与Cys C、PTH和BGP呈负相关,r分别是-0.39、-0.43、-0.32,与血Ca、P、CT和ALP无相关性。Cys C与PTH和BGP呈正相关(r分别是0.38、0.25)。结论 CRF患者BMD显著下降,可能与肾脏损伤程度和钙调节激素紊乱有关。Objective To investigate the relationship among bone mineral density （BMD）, calcium regulation hormones, and eystatin C in patients with chronic renal failure. Methods Dual energy X-ray absorptiometry （DEXA） was used to measure BMD of 75 patients with chronic renal failure （CRF） and 50 normal control people. Individual biochemical parameters, including serum calcium （Ca）, phosphorus （P）, alkaline phosphatase （ALP）, cystatin C （Cys C） and calcium regulation hormones, including parathyroid hormone （PTH）, calcitonin （CT）, bone gal protein （BGP）, were measured and analyzed statistically. Results BMD of the patients in CRF group were significantly lower than that in the control group （P 〈 0.01 ）. P, ALP, PTH, BGP, and CT increased significantly （P 〈 0. 01 ）. Ca decreased significantly （P 〈 0. 01 ）. BMD was negatively associated with Cys C, PTH, and BGP （r = - 0. 39, - 0. 43, and -0.32, respectively）. No correlation was found among BMD and Ca, P, CT, and ALP. Cys C was positively correlated with PTH and BGP （ r = 0. 38 and 0. 25, respectively）. Conclusion BMD decreased significantly in CRF patients, which was probably associated with the degree of kidney damage and the disturbance of calcium regulation hormnnes.

关 键 词：慢性肾功衰 骨密度 钙调节激素 胱抑素C 

分 类 号：R446.1[医药卫生—诊断学]