复方654—2对中老年人急性高原反应预防效果的研究  

EFFECTS OF COMPOUND CAPSULE ANISODAMINE-2(654-2) ON PREVENTION OF ACUTE HIGH ALTITUDE RESPONSE IN MIDDLE-OLD-AGED PERSONS

作　　者：李朝斌[1] 刘一兵[1] 张素萍[1] 秦必文[1] 朱永安[1] 茹仙姑丽 

机构地区：[1]新疆军区高山病研究所,844900

出　　处：《高原医学杂志》1999年第4期29-32,共4页Journal of High Altitude Medicine

摘　　要：目的：探讨和研究中老年急性高原反应（ＡＭＳ）有效的药物防治。方法：对平原急进海拔５ ４００ｍ 的中老年人随机分为口服复方６５４—２（ｎ＝ １５）、复方党参（ｎ＝ １２）和空白对照（ｎ＝ １２）。上高原服药后随访进入３ ８００ｍ 、４ ２００ｍ 和５ ４００ｍ 高原时的ＡＭＳ情况，同时测血压，在返回３ ８００ｍ 时检测心电图、血液动力学。结果：与对照组比较，在４ ２００ｍ以下，两组药物对ＡＭＳ均有较好的预防效果（Ｐ＜ ０．０５和Ｐ＜ ０．０１），在５ ４００ｍ 时，复方６５４—２ 对降低ＡＭＳ的反应率，对减轻反应程度更显著（Ｐ＜ ０．０５ 和Ｐ＜ ０．００１），复方党参不显著（Ｐ＞ ０．０５）。结论：两种药物预防中老年ＡＭＳ均有较好的效果，在５ ４００ｍ 特高海拔对于降低ＡＭＳ的反应率和反应程度，以及ＰＡＷＰ、ＴＰＲ、ＨＯＩ，提高ＶＰＥ、ＳＶＬ、ＢＶ和稳定血压等，复方６５４—２ 明显优于复方党参。二者合用，可能是选择防治中老年人ＡＭＳ有效药物途径。To observe the effects of compound capsule 654-2 on prevention of acute high altitude response in middle-old-aged persons.Methods:A total of subjects,middle-old-aged(45～60 years old)who were acutely exposed to 5 400m from sea level,were divided randomly into three groups,viz.oral 654-2 group (15 cases),oral dangsheng group(12 cases)and control(12 cases).Expresses of AMS at 3 800m,4 200m and 5 400m altitudes were recorded and BP CEG and parameters of hemodynamics were examined.Results:654-2 and Dangsgeng had a beneficial preventive effect ( P <0 05 and <0 01)on AMS at altitude of 4 200m but compound 654-2 was better at 5 400m as compared with control.Conclusion:Compound capsule 654-2 and Dangsheng have preventive effcts on AMS,especially formar.The preventive effect coule be better when the capsule 654-2 combine with capsule Dangsheng to adminstrate in middle-old-aged persons.$$$$

关 键 词：中老年人 急性 高原反应 复方654-2 复方党参 

分 类 号：R594.3[医药卫生—内科学]