取代芳(硫)醚硝基物的水合肼催化还原研究  

Study on catalytic hydrazine reduction of substituted aromatic(thio) ether nitro compounds

作　　者：张玉杰 

机构地区：[1]陕西汉江药业集团股份有限公司,陕西汉中723000

出　　处：《化学工程师》2011年第7期61-63,共3页Chemical Engineer

摘　　要：取代芳（硫）醚氨基化合物是重要的制药中间体,本文采用FeCl3.6H2O/C催化下水合肼还原取代芳（硫）醚硝基物,高收率、高纯度制得取代芳（硫）醚氨基化合物。该工艺具有操作方便、后处理简单等特点,反应过程易操控,对设备要求不高,安全可靠,对环境污染小,更适合于工业化生产。4个实例产物收率为85.0%~95.3%,GC纯度为97.6%~99.3%。Substituted Aromatic（thio）ether nitro compounds are extremely important pharmaceutical intermediates.In this paper,FeCl3.6H2O/C-catalyzed hydrazine is used in the reduction of substituted aromatic（thio）ether nitro compounds,to produce high-yield and pure compounds.The process is easy to operate and simple post-processing features.It is also more suitable for industrial production because it is easy to control the reaction process,less demanding on the equipment,safe,reliable,and with minimum environmental pollution.Four test product yield was up to 85.0%~95.3%,with GC purity of 97.6%~99.3%.

关 键 词：水合肼 中间体 硝基物 还原 

分 类 号：O626[理学—有机化学]