Anti-CCP及CRP对类风湿关节炎活动度及骨侵蚀的预测价值  

The prediction value of combinational detection of Anti-CCP and CRP on rheumatoid arthritis activity and bone erosion

作　　者：汪健[1] 李华[1] 鲁勇 段志兵[1] 叶印泉[1] 贾龙梅[1] 曹莉萍[1] 王伶[1] 

机构地区：[1]南昌大学第二附属医院,南昌330006 [2]江西省新建县人民医院,新建330100

出　　处：《江西医药》2011年第6期505-507,共3页Jiangxi Medical Journal

基　　金：江西省卫生厅课题(20091155)

摘　　要：目的探讨Anti-CCP及CRP在RA活动度及骨侵蚀中的临床预测价值。方法随访收集的56例RA患者和30例健康体检者,采用ELISA、速率散射比浊法联合检测抗环瓜氨酸多肽抗体(Anti-CCP)和C-反应蛋白(CRP),结合手、足X线片变化分析Anti-CCP及CRP与RA活动度及骨侵蚀的关系。结果 Anti-CCP及CRP在早期RA组与非早期RA组之间比较差异无统计学意义(P>0.05),RA活动组与缓解组、骨侵蚀组与非骨侵蚀组比较差异有统计学意义(P<0.05)。结论 Anti-CCP及CRP联合检测对RA活动度及骨侵蚀可能具有临床预测价值。Objective To investigate the clinical significance of combinational detection of Anti-CCP and CRP in Rheumatoid Arthritis（RA） activity and bone erosion.Methods Anti-CCP and CRP of 56 cases of RA patients and 30 cases of health control were detected by ELISA and the rate nephelometry combined with hand and foot x-ray films,were compared between early RA group and non-early RA group,activity group and inactivity group,bone erosion group and non-bone erosion group.Results Anti-CCP and CRP were both elevated significantly in RA patients compared to the health control;Anti-CCP and CRP in the early RA group and the non-early RA group had no significant difference（P0.05）;there was significant difference（P0.05）between activity group and non-activity group,bone erosion group and non-bone erosion group.Conclusion It＇s ability valuable to predict the activity and bone erosion of RA,using combinational detection of Anti-CCP and CRP.

关 键 词：类风湿关节炎 抗环瓜氨酸多肽抗体 C-反应蛋白 

分 类 号：R593.22[医药卫生—内科学]