硫辛酸治疗糖尿病周围神经病变的疗效  

Treatment of Diabetic Peripheral Neuropathy with Lipoic Acid

作　　者：熊燕[1] 张太阳[2] 秦淑兰[1] 颜玲仙[1] 赖晓阳[1] 张美英[1] 

机构地区：[1]南昌大学第二附属医院内分泌代谢科 [2]南昌市第二医院内分泌科,南昌330006

出　　处：《实用临床医学（江西）》2011年第4期21-22,25,共3页Practical Clinical Medicine

摘　　要：目的探讨硫辛酸(ALA)治疗糖尿病周围神经病变的疗效。方法将119例糖尿病周围神经病变(DPN)患者按随机数字表法分为治疗组(60例)和对照组(59例)。治疗组给予基础治疗的基础上加用ALA注射液300 mg加入0.9%氯化钠注射液250 mL中静脉滴注,闭光,1次.d-1,1 h内点完,10 d 1个疗程;对照组给予基础治疗的基础上加用维生素B1100 mg、维生素B12500μg肌内注射,1次.d-1,15 d 1个疗程。对2组患者治疗前后的疗效及神经传导速度的改善情况进行比较。结果治疗组有效率为88.3%,对照组有效率为39.0%,2组比较差异有统计学意义(P<0.05);治疗组正中神经、腓总神经运动传导速度(MNCV)及感觉传导速度(SNCV)均较治疗前明显增快,其改善程度明显好于对照组(P<0.05或P<0.01)。结论 ALA治疗DPN疗效显著,且无明显不良反应,是治疗DPN一种有效的药物。Objective To investigate the efficacy of lipoic acid（ALA） in the treatment of diabetic peripheral neuropathy（DPN）.Methods A total of 119 patients with DPN were randomly divided into treatment group（n=60） and control group（n=59）.The treatment group received 10-day course of intravenous infusion of ALA（300 mg in 250 mL 0.9% normal saline,closed-ray,finish within 1 hour,once daily）.The control group were treated with 15-day course of intramuscular injection of vitamin B1（100 mg） and vitamin B12（500 μg） once daily.The efficacy and improvement in nerve conduction velocity following treatment were compared between the two groups.Results The effective rate in treatment group was significantly higher than that in control group（88.3% vs 39.0%,P0.05）.ALA resulted in an obvious improvement in median nerve and peroneal nerve motor conduction velocity and sensory nerve conduction velocity,and the improvement in treatment group was better than that in control group（P0.05 or P0.01）.Conclusion ALA is effective in the treatment of DPN and does not lead to obvious adverse reactions.

关 键 词：糖尿病周围神经病变 硫辛酸 维生素B1 维生素B12 

分 类 号：R587.1[医药卫生—内分泌]