非亲缘异基因造血干细胞移植后出血性膀胱炎的防治策略  

PREVENTION AND TREATMENT OF HEMORRHAGIC CYSTITIS IN NONRELATIVE ALLOGENETIC HEMATOPOIETIC STEM CELL TRANSPLANTATION

作　　者：邓婷芬[1] 李庆山[1] 许世林[1] 

机构地区：[1]广州市第一人民医院,广东广州510180

出　　处：《现代医院》2011年第7期22-24,共3页Modern Hospitals

基　　金：广东省科技计划基金资助项目(编号:2008B030301263)

摘　　要：目的探讨常规预防方案干预下,非亲缘异基因造血干细胞移植(Allogenetic hematopoietic stem cell trans-plantation,Allo-HSCT)后出血性膀胱炎(hemorrhagic cystitis,HC)的发病情况、危险因素和有效的防治方法。方法对10例恶性血液病患者行非亲缘Allo-HSCT的回顾性分析,移植过程中均进行常规的HC、移植物抗宿主病(graft versus host dis-ease,GVHD)和巨细胞病毒(cytomegalovirus,CMV)感染的预防。分析移植后HC发生的特点及与移植类型、其他临床特征的关系和防治效果。结果共8例发生HC(8/10),平均发病时间为26.88天,平均病程为19.3天;其中5例发生CMV感染同时合并aGVHD,1例仅出现aGVHD,另2例两者皆无。经治疗后7例完全缓解,1例死亡。结论非亲缘Allo-HSCT在采取充分的预防措施后,HC多为早期发生,程度较轻,治疗效果良好;其发病与供者类型、HLA的匹配程度、aGVHD和CMV感染密切相关。Objective To explore the characteristics, risk factors, effective prevention and treatment of hemorrhagic cystitis （HC） in patients after nonrelative allogenetic hematopoietic stem cell transplantation （Allo -HSCT）receiving routine prophylaxis for HC. Methods 10 patients with hemotologic malignancy after nonrelative Allo - HSCT were studied, we adopted routine prophylaxis for HC, graft versus host disease （GVHD） and cytomegalovirus （CMV） infection. The relationship between HC and transplantation type or other clinical features was analyzed. The curative effect was observed. Results Eight cases showed early HC, the median onset time of HC was 26. 88 days after transplantation, the median persistence time was 19.3 days; five cases were combined with aGVHD and CMV infection, one case only appeared aGVHD, another two were nothing. Seven cases were complete remission, one case dead. Conclusion After full prevention, most HC in patients after nonrelative Allo - HSCT were early onset, no severity and better therapeutic efficacy, which may be closely related to donor type, HLA match, aGVHD and CMV infection.

关 键 词：出血性膀胱炎 巨细胞病毒感染造血干细胞移植 

分 类 号：R457.7[医药卫生—治疗学]