重组人生长激素对烧伤后高代谢的影响  

EFFECT OF RECOMBINANT HUMAN GROWTH HORMONE THERAPY ON HYPERMETABOLISM POSTBURN

作　　者：郝岱蜂 郭振荣[1] 贺立新[1] 韩翠华[1] 盛志勇[1] 卜林[2] 王琪 白晓慧 

机构地区：[1]北京解放军第304医院柴家科,100037 [2]长春金赛药业有限公司

出　　处：《解放军医学杂志》1999年第6期417-419,共3页Medical Journal of Chinese People's Liberation Army

基　　金：全军"九.五"医学科研规划指令性课题!(编号96L043)

摘　　要：为探讨重组人生长激素（ｒｈＧＨ）对烧伤后高代谢反应的影响，采用实验用小型香猪ＴＢＳＡ ３５％ Ⅲ度烧伤模型，动态观察了ｒｈＧＨ对静息能量消耗（ＲＥＥ）、血清生长激素、胰岛素样生长因子－１（ＩＧＦ－１）、胰岛素、胰高血糖素、皮质醇、白蛋白及体重等代谢相关指标的影响。结果发现，ｒｈＧＨ 能明显降低烧伤后ＲＥＥ水平，并使血清生长激素、ＩＧＦ－１、白蛋白及体重较对照组显著升高，但对胰岛素、胰高血糖素和皮质醇等无明显影响。表明严重烧伤后应用ｒｈＧＨ治疗有明显降低高代谢的作用。To determine the effect of recombinant human growth hormone (rhGH) on postburn hypermetabolism postburn, sixteen male minipigs were inflicted with 35% TBSA full thickness burns, and the burned minipigs were then randomly divided into two groups: rhGH group and control group. REEs were monitored by means of Cardiorespiratory Diagnostic Systems (Medical Graphics Corporation, USA). The sequential changes in serum levels of GH, IGF 1,insulin,glucagon,cortisol,albumin were analyzed. The level of REE is significantly lower in rhGH treated groupas as compared with that of control, while the serum concentrations of GH, IGF 1, albumin are higher in the former, Body weighf gain is observed in rhGH treated group with no significant effect on serum concentration of insulin,glucagon and cortisol. RhGH therapy is thus helpful in the control of hypermetabolism after extensive burn.

关 键 词：烧伤 生长激素 生长调节素 能量代谢 RHGH 

分 类 号：R644[医药卫生—外科学]