环维黄杨星D对异丙肾上腺素致小鼠心肌肥厚保护作用的初步研究  

Preliminary Study of Protective Effect of Cyclovirobuxinum D on Cardiac Hypertrophy Induced by Isoprenaline in Mice

作　　者：周园[1] 吴俊标[1] 刘爱军[2] 陈孝健[1] 潘立行[1] 周玖瑶[1] 

机构地区：[1]广州中医药大学中药学院,广州510006 [2]广州中医药大学基础医学院

出　　处：《中国药师》2011年第7期919-921,共3页China Pharmacist

基　　金：广州中医药管理局课题(编号:2009231)

摘　　要：目的:初步研究环维黄杨星D(Cvb-D)对小鼠心肌肥厚的保护作用。方法:皮下注射异丙肾上腺素(Iso)1mg·kg^(-1),bid,连续14d,制备小鼠心肌肥厚模型,各治疗组分别给予环维黄杨星D(6,9,12mg·kg^(-1))和阳性对照卡托普利(100mg·kg^(-1))灌胃给药,末次给药24h后处死小鼠,测量小鼠心脏质量指数(全心质量/体质量)和左心室质量指数(左心室质量/体质量),并观察心肌组织病理形态学改变,以评价Cvb-D对小鼠心肌肥厚的保护作用。结果:与空白对照组比较,Iso模型组小鼠心脏重量指数明显升高,病理切片可见心肌肥厚改变。与Iso组相比,Cvb-D高剂量组能明显降低小鼠心脏质量指数和左心室质量指数(P<0.05或0.01),病理切片可见损害较模型组减轻。结论:环维黄杨星D对Iso诱导的小鼠心肌肥厚具有一定的保护作用,其机制有待进一步研究阐明。To study the protective effect of cyclovirobuxinum D （Cvb-D） on cardiac hypertrophy induced by isoprenaline （Iso） in mice. Method： Mice cardiac hypertrophy model was established by administration of isoproterenol （Iso） 1 mg·kg^-1 sc, twice daily for 14 days. The therapy groups were intragastric administration of Cvb-D （6,9 and 12 mg·kg^-1） or captopril （100 mg· kg^-1 ）. The heart weight index （heart weight/body weight, HW/BW）, left ventricular weight index （left ventricular weight/body weight, LVW/BW） and myocardial morphological changes were determined to evaluate the protective effect of Cvb-D on cardiac hypertrophy. Result： Compared with those of control group, the HW/BW and LVW/BW of Iso group obviously increased, and the pathologic changes could be seen. Cvb-D （ 12 mg·kg^-1 ） could obviously decrease the heart indices in mice （P 〈0. 05 or P 〈0. O1 ） ,and also improve the pathologic damages of cardiac hypertrophy. Conclusion ： Cvb-D can inhibit cardiac hypertrophy induced by Iso, and the mech anism needs to be further studied.

关 键 词：环维黄杨星D 心肌肥厚 异丙肾上腺素 

分 类 号：R542.2[医药卫生—心血管疾病]