参麦皂苷促进环磷酰胺化疗小鼠免疫和造血功能恢复实验研究  

Experimental Study on the Promotion Effect of Ginseng-Ophiopogonis Saponin on the Hemato-Immunological Recovery in Mice Receiving Cyclophosphamide Chemotherapy

作　　者：陈浩凡 周长华[2] 谭敏谊[3] 陈健文[2] 

机构地区：[1]广东省边防总队医院,广东深圳518029 [2]中山大学药学院 [3]中山大学附属第一医院心血管科

出　　处：《中国药师》2011年第7期926-928,共3页China Pharmacist

摘　　要：目的:研究参麦皂苷对环磷酰胺化疗损伤模型小鼠免疫功能和造血功能恢复的促进作用。方法:注射环磷酰胺复制小鼠免疫低下模型,造模后给予参麦皂苷治疗,观察小鼠外周血细胞计数、网织红细胞数、骨髓有核细胞数,脾结节数,体质量、胸腺系数和脾脏系数的变化。结果:参麦皂苷可明显升高模型小鼠白细胞数、血红蛋白含量和血小板数(P<0.05),增加网织红细胞数和脾结节数(P<0.05),增加体质量、脾脏和胸腺指数(P<0.05)。结论:参麦皂苷具有显著改善机体免疫功能和刺激骨髓造血功能的作用。The recovery promotion effect of Ginseng-ophiopogonis saponin （GOS） on the hematological and immunological funetions of eyelophosphamide-induced mice injury was studied. Method： Immunosuppression mice model was established by intraperitoneal injection of cyelophosphamide. Body weight, routine blood test, counting of reticulocyte, bone marrow nucleated ceils and colony forming unit of spleen（ CFU-S）, and the coefficients of thymus and spleen were determined after the administration of GOS. Result： Compared with the control group, the levels of peripheral blood leukoeytes, platelets and hemoglobin were significantly increased （ P 〈 0. 05 ） , the numbers of retieuloeyte and CFU-S were remarkably aseended（ P 〈 0. 05 ） , and the body weight and coefficients of thymus and spleen were higher in GOS group as well （ P 〈 0.05 ）. Conclusion： GOS can significantly improve immune function and promote the hematopoietic function of bone marrow.

关 键 词：参麦皂苷 环磷酰胺 免疫 

分 类 号：R285.5[医药卫生—中药学]