别嘌呤醇用药调查及其药疹患者HLA-B 5801基因型分析  

Analysis of Allopurinol Medication and HLA-B~* 5801 Genotype of Patients with Drug Eruption

作　　者：张亚同[1] 时正媛[2] 胡欣[1] 孙春华[1] 李可欣[1] 杨莉萍[1] 

机构地区：[1]卫生部北京医院药学部,北京100730 [2]沈阳药科大学

出　　处：《中国药师》2011年第7期952-954,共3页China Pharmacist

基　　金：卫生行业科研专项基金(编号:200902008-03)

摘　　要：目的:调查别嘌呤醇用药情况并分析可能引起别嘌呤醇皮疹的HIA-B~*5801基因型。方法:收集我院应用别嘌呤醇患者的人口流行病学特征,分析发生皮疹患者的HIA-B~*5801基因型。结果:监测服用别嘌呤醇患者421名,别嘌呤醇平均剂量145.8mg·d^(-1)。4例患者分别出现单纯斑丘疹、结节性药疹、慢性荨麻疹和大疱型类天疱疮等药疹,其中仅1例患者检测出HLA-B~*5801。结论:我院患者别嘌呤醇用药剂量小于成人最大量,严重药疹发生率低,HIA-B~*5801与别嘌呤醇致严重皮疹的相关性有待进一步确证。To analyze the allopurinol medication and HLA-B ＊ 5801 genotype of the patients with drug eruption after administration. Method： A prospective analysis was used to study epidemiological characteristics of the patients administered allopurinol in our hospital. The patients with drug eruption possibly caused by allopurinol, especially severe ones, were monitored. The blood samples were collected to analyze HLA ＊ B5801 genotype. Result： There were 421 patients administrated allopurinol altogether. The mean dose of allopurinol was 145.8 mg·d^-1. Only four cases were diagnosed as drug eruption caused by allopurinol and among them, only one patients showed HLA-B ＊ 5801 positive by the PCR-SSP test. Conclusion： The patients with hyperuricemia or gout in our hospital were generally elder people ,whose allopurinol dosage was less than the maximum dosage for adults with lower incidence of serious rash. The definite relationship between HLA-B ＊ 5801 genotype and severe rash induced by allopurinol has not shown in the study which should be researched further.

关 键 词：别嘌呤醇 基因型 HLA-B*5801 药疹 

分 类 号：R968[医药卫生—药理学]