RP-HPLC法测定复方二氧丙嗪茶碱片的含量及含量均匀度  

Determination of Content and the Content Uniformity of Compound Dioxopromethazine Hydrochloride Tablets by RP-HPLC

作　　者：孙洪刚[1] 李百强[2] 贾首时 张杰[3] 

机构地区：[1]齐齐哈尔市第一医院,齐齐哈尔161005 [2]黑龙江省药品不良反应监测中心 [3]齐齐哈尔医学院药学院

出　　处：《中国药师》2011年第7期983-984,共2页China Pharmacist

摘　　要：目的:建立RP-HPLC法测定复方二氧丙嗪茶碱片中盐酸二氧丙嗪的含量及含量均匀度。方法:色谱柱为Agilent-C_(18)(150mm×4.6mm,5μm)柱;流动相为水-乙腈-三乙胺(90:10:0.2);流速为1.0ml·min^(-1);检测波长:226nm。结果:盐酸二氧丙嗪在5.04～100.76μg·ml^(-1)范围内线性关系良好(r=0.9997);平均加样回收率为99.04%,RSD=0.17%(n=9)。结论:本法专属性强,操作简便,结果准确可靠。To establish a method for the determination of content and content uniformity of dioxopromethazine in compound dioxopromethazine hydrochloride tablets by RP-HPLC. Method： The column was Agilent-Cls （150mm × 4. 6mm,5 μm） with wa- ter - acetontrile - triethylamine （90： 10： 0. 2） as the mobile phase at a flow rate of 1.0 ml·min^-1 and UV detection wavelength was at 226 nm. Result： The linear range of dioxopromethazine was 5.04-100. 76μg.m1^-1. The average recovery was 99. 04% , RSD =0. 17 （ n = 9 ）. Conclusion ： This method is specific, simple and accurate.

关 键 词：盐酸二氧丙嗪 荼碱 盐酸克仑特罗 反相高效液相色谱 

分 类 号：R927.2[医药卫生—药学]