2008-2009年北京市男男性行为者HIV-1感染率与新发感染率调查  

A survey of HIV prevalence and incidence in men who have sex with men in Beijing,2008-2009

作　　者：陈强[1] 李洋[1] 孙燕鸣[1] 卢红艳[1] 沈圣[2] 蒋岩[2] 

机构地区：[1]北京市疾病预防控制中心性病艾滋病防治研究所,100013 [2]中国疾病预防控制中心艾滋病控制中心,北京102206

出　　处：《中国医药生物技术》2011年第4期270-273,共4页Chinese Medicinal Biotechnology

摘　　要：目的了解北京市男男性行为者（MSM）人群HIV-1感染率与新发感染率情况。方法对北京市2008—2009年三轮MSM人群进行横断面调查，采用酶联免疫吸附试验（ELISA）与蛋白印迹实验（WB）对监测样本进行初筛与确证实验。再对血清学确认为HIV-1阳性的样本进行BEDHⅢ捕获酶联法（BED方法）检测。结果在1833份监测样本中共筛出96份HIV-1阳性样本，其中进行BED方法检测的样本数为68例，判定为新近感染的样本为36例。三轮MSM人群HIV感染率分别为5．9％、5．0％、4．9％；三轮MSM人群新发感染率分别为4．83％（2．36％～7．54％）、4．83％（2．36％～7．54％）、2．65％（0．82％～4．55％）。结论北京市2008～2009年度MSM人群HIV的感染率与新发感染率均达到较高水平。Objective To estimate HIV prevalence and incidence in men who have sex with men （MSM） in Beijing, and also to explore HIV epidemic trends in this population. Methods Samples of men who have sex with men were three rounds collected during the year of 2008 - 2009, and ELISA and wstern blot assays were used to detect HIV antibody as screening and confirmatory tests. Samples confirmed as HIV-1 positive were further tested with BED HIV-1 incidence capture enzyme immunoassay （BED-CEIA） to find recent HIV-1 infection, and the HIV-1 incidence for each year was then calculated. Results Total 1833 samples were tested for ELISA and western blot, and 96 samples were confirmed as HIV-1 positive. 68 HIV-1 positive samples were then tested with BED-CEIA and 36 of them were identified as recent infections. The HIV prevalence of men who have sex with men were 5.9%, 5.0%, 4.9% for each round during 2008 - 2009, while the corresponding incidence were 4.83% （2.36% - 7.54%）, 4.83% （2.36% - 7.54%）, 2.65% （0.82% - 4.55%）. Conclusion HIV-1 prevalence and incidence among MSMs declined during the year of 2008 - 2009 in Beijing.

关 键 词：同性恋 男性 HIV-1 HIV感染 BED HIV-1捕获酶联法 

分 类 号：R512.91[医药卫生—内科学]