128名化疗后Ⅳ度骨髓抑制患者使用硫酸依替米星疗效及安全性研究  

Efficacy and safety of etimicin used in 128 chemotherapy patients with grade Ⅳ bone marrow depression

作　　者：陈龙[1] 黄亚琼[1] 杨文元[1] 

机构地区：[1]兰州军区兰州总医院肿瘤科,甘肃兰州730050

出　　处：《甘肃医药》2011年第8期461-463,共3页Gansu Medical Journal

摘　　要：目的:评价硫酸依替米星注射液治疗化疗后Ⅳ度骨髓抑制伴发热癌症患者的临床疗效和药物不良反应。方法:回顾性分析2005年1月至2010年10月非随机选择128例癌症患者医院化疗后Ⅳ度骨髓抑制伴发热,给予硫酸依替米星联合左氧氟沙星联合经验性抗感染治疗,观察感染指标,评估疗效及不良反应。结果:128例患者经硫酸依替米星联合左氧氟沙星抗感染治疗后,114例患者平安度过重度骨髓抑制期,体温恢复正常。平均使用抗生素退热时间(3.4±1.7)天。不良反应发生率为2.3%,为轻度眩晕、耳鸣及皮疹。结论:硫酸依替米星治疗化疗后Ⅳ度骨髓抑制伴发热癌症患者疗效好,见效快,不良反应较少,是较理想的抗感染药物。Objective：To observe the efficacy and adverse reaction of etimicin sulfate injection by dripping on the grade Ⅳ bone marrow depression cancer patients with fever after chemotherapy. Methods：During Jan 2005 to Oct 2010,128 cases of the grade Ⅳ bonemarrow depression cancer patients with fever after chemotherapy were used combining etimicin sulfate injection with levofloxacin of empirical anti-infection therapy in which infection index,curative effect and adverse reaction rate were observed. Results：Of 128 patients,114 patients safely survived over dangerous period with the combined treatment in which the temperature recovered normal level,the using etimicin of average utility time was（3.4±1.7） days and the adverse reaction rate was 2.3% mainly including mild dizziness,tinnitus and rash. Conclusion：The etimicin sulfate injection is efficient and safe in the treatment for the grade Ⅳ bone marrow depression cancer patients with fever after chemotherapy.

关 键 词：骨髓抑制 硫酸依替米星注射液 经验性抗感染治疗 疗效 安全性 

分 类 号：R927.1[医药卫生—药学]