老年2型糖尿病患者的血清脂蛋白(a)水平及其与颈动脉硬化程度的关系  

THE RELATIONSHIP BETWEEN SERUM LIPOPROTEIN(A) LEVELS AND CAROTID ARTERY ATHEROSCLEROSIS IN TYPE-2 DIABETES MELLITUS

作　　者：银孟卓[1] 卢建文[1] 

机构地区：[1]广州市第一人民医院,广东广州510180

出　　处：《现代医院》2011年第8期63-65,共3页Modern Hospitals

摘　　要：目的探讨老年2型糖尿病患者血清脂蛋白(a)[lp(a)]水平及其与颈动脉狭窄程度的关系。方法选择80例2型糖尿病老年患者及78例健康对照者,测定其血清lp(a)、总胆固醇(TC),甘油三脂(TG)、低密度脂蛋白(LDL-C)水平及颈动脉狭窄情况。结果糖尿病不同狭窄程度的四组组间的TC、TG、LDL-C均无显著性差异(p>0.05),与对照组比较有显著性差异(p<0.05);糖尿病患者的lp(a)值随颈动脉狭窄程度的增加而升高,成正比关系。结论 lp(a)在2型糖尿病患者血清中显著升高,且随着颈动脉狭窄程度的增加而升高,血清lp(a)测定可以作为糖尿病颈动脉硬化的预测指标之一。Objective To explore the relationship between lipoprotein（a） and Carotid artery atherosclerosis in type - 2 diabetes mellitus. Methods Serum lipoprotein（ a）, total cholesterol （ TC）, triglyceride （ TG）, low den- sity lipoprotein cholesterol （LDL- C）, and carotid artery intima- media thickness （IMT） were detected in 80 type - 2 diabetic patients and 78 healthy control subjects. Results The levels of lp （a）, TG, TC, LDL - C in the diabetic group were significantly higher than the control group. And lp（a） value were increased positively with the IMT. Con- clusion Lp（a） level in the diabetic patients was significantly increased, and related to IMT values. The serum lp （a） can be used as a predictive risk factor for atherosclerosis in diabetic patients.

关 键 词：2型糖尿病 脂蛋白(a) 颈动脉 粥样硬化 

分 类 号：R587.1[医药卫生—内分泌]