某院578例药品不良反应报告分析  

Analysis on 578 Adverse Drug Reaction Case Reports

作　　者：金剑[1] 肖忠革[1] 金芝贵[1] 吴飞华[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院药剂科,上海200011

出　　处：《中国医药指南》2011年第21期178-180,共3页Guide of China Medicine

基　　金：上海医院药学科研基金(编号:2010-YY-02-7)

摘　　要：目的了解上海交通大学医学院附属第九人民医院药品不良反应(ADR)的发生情况及引发ADR的相关因素。方法对上海交通大学医学院附属第九人民医院2005年1月至2010年12月收集到的578例ADR进行回顾性统计与分析。结果 578例ADR报告中,女性多于男性,65岁以上老年患者占总例数的48.1%。给药方式中,静脉滴注引发的ADR最多,口服第二。涉及的药品种类中,抗感染药物居首位,其次是心血管药物,中药和解热镇痛药分别为第三、第四位。引起ADR的抗感染药中,喹诺酮类药物占首位,头孢菌素类药物居第二位,依次是林可霉素类、β-内酰胺酶抑制类。ADR的临床表现形式以过敏、消化系统反应比较多见。结论上海交通大学医学院附属第九人民医院ADR的发生以女性、老年患者居多,其临床表现多样,发生因素与患者年龄、给药途径、药品种类等相关。应加强对ADR的监测及相关知识的宣传,以减少和避免ADR的发生。Objective To observe the occurrence of ADR in Affiliated No.9th People＇s Hospital,Medical College of Shanghai Jiaotong University and analyze its correlative factors.Methods：The 578 case reports of ADR collected from Jan 2005 to Dec 2010 in Affiliated No.9th People＇s Hospital,Medical College of Shanghai Jiaotong University and were analyzed statistically.Results Of the 578 patients,Females were more than males,There were 48.1%of patients who were older than 65.Most of them were resulted from iv which accounted for 64.53%（373 cases）,induced by po which accounted for 33.22%.Antimicrobial drug was the first of all the drugs involved in the present study,and the next one was cardiovascular drugs.The third and fourth category were traditional Chinese medicine,antipyretic and analgesic.Of all the antimicrobial drugs,Fluoroquinolones was accounted for 38.91%of that of ADR induced by Antimicrobial drug.The second were Cephalosporins.Various ADR were discovered.Of the 578 ADR cases,most commonly manifested itself in the anaphylactic reaction.Conclusions The ADR of female and older patients in Affiliated No.9th People＇s Hospital,Medical College of Shanghai Jiaotong University occurs commely and clinical manifestations of ADR varies.The occurrence of ADR is related to many factors,such as age of patients,administration route and category of drug.ADR monitoring should be strengthened and knowledge of ADR should be publicized so as to lessen and avoid the occurrence of ADR.

关 键 词：药品不良反应 监测 

分 类 号：R969.2[医药卫生—药理学]