泌尿系细菌L型感染病原菌分布及耐药性分析  

The Distribution and Drug Resistance of Pathogenic Bacteria L in Urinary Infection

作　　者：吴雪平[1] 王静[1] 杨萍[2] 

机构地区：[1]安徽省蚌埠医学院第一附属医院肾内科,233004 [2]安徽省蚌埠医学院第一附属医院检验科,233004

出　　处：《中华全科医学》2011年第9期1337-1337,1342,共2页Chinese Journal of General Practice

基　　金：安徽省卫生厅科研基金项目(06B085)

摘　　要：目的探讨泌尿系细菌L型感染病原菌分布及耐药性,为临床合理选用抗菌药物提供依据。方法对188例次泌尿系细菌L型感染患者进行尿标本细菌培养及药敏试验,采用K-B法进行药物敏感试验。结果泌尿系细菌L型感染以革兰阴性杆菌为主,其次为革兰阳性球菌、真菌。其中大肠埃希菌居第1位,占37.77%,占革兰阴性杆菌的63.39%;其次,肠球菌属占16.49%,葡萄球菌属占9.57%,念珠菌属占8.51%。药敏试验显示,泌尿系细菌L型感染病原菌对多种抗菌药物产生了不同程度的耐药性,但革兰阳性球菌对万古霉素、大部分革兰阴性杆菌对亚胺培南敏感率为100.0%,鲍曼不动杆菌、克雷伯杆菌对亚胺培南呈不同程度耐药;产超广谱β-内酰胺酶(ESBLs)大肠埃希菌检出率是28.17%。结论泌尿系细菌L型感染病原菌以条件致病菌为主,且耐药性较为严重,应采取有效措施控制耐药菌的流行趋势。Objective To investigate the distribution and drug resistance of pathogenic bacteria L in urinary infection, and to provide the basis for clinical rational choose of antimicrobial agents. Methods Bacteria culture and drug susceptibility test with K-B method were performed among 188 samples from urinary tract bacteria L infection patients. Results Urinary tract infection with bacteria L was primarily negative bacillus,followed by Gram positive coccus,fungi. Among them,Escherichia coli accounted 37.77%, accounting for 63.39% of gram-negative bacilli ; Enterococcus genus accounted for 16.49%, staphylococcus genus accounted for 9.57%, candida genus 8.51%. Antimicrobial susceptibility test showed： urinary tract infection of various pathogenic bacteria L antimicrobial produced different degree of resistance,but gram-positive cocci to vancomycin, most gram-negative bacilli imipenem sensitive to rate of 100.0%, acinetobacter baumannii, crayresearch influenzae to imipenem assumed different degree resistance;produce super broad-spectrum beta-lactamase（ESBLs） escherichia coli detection rate was 28.17%. Conclusion Urinary tract infection with conditions pathogenic bacteria L main and resistant pathogens were relatively serious, effective measures should be taken to control the popular trend of antibiotic resistant bacteria.

关 键 词：泌尿系感染 细菌L型 耐药性 

分 类 号：R691.3[医药卫生—泌尿科学]