应用于无标记质谱定量分析的生物信息学软件研究进展  

Research progress on bioinformatics softwares involved in unmarked mass spectrometry based quantitative proteomics

作　　者：忻骥文[1] 江松敏[1] 

机构地区：[1]复旦大学生命科学院,上海200443

出　　处：《植物检疫》2011年第4期65-69,共5页Plant Quarantine

摘　　要：在过去的10年间,伴随着蛋白质组学定量质谱实验技术的发展,产生了大量相应的数据处理手段。本文阐述了定量质谱的主要实验手段及其原理,介绍了不同无标记质谱数据分析软件的特点及其用途,并列举已有的常用定量质谱数据分析软件类型。本综述对研究人员更好地寻找适合实验目的的计算机软件以及编写新型数据分析软件具有一定的参考价值。In the past decade,several experimental methods for MS-based quantitative proteomics and corresponding computational methodology for the processing of the resulting data have emerged.Here we provide an overview of the major quantification principles and available softwares for the analysis of data generated by LC-MS.In addition,advantages and challenges of each available software were evaluated.This review provided some references for researchers to choose the appropriate software for quantitative proteomic experiments based on their experimental and analytical requirements.

关 键 词：蛋白质组学 生物信息学 无标记定量 

分 类 号：S41[农业科学—植物保护] S126