浙江省健康体检人群乙肝标志物血清学模式分析  

Distribution characteristics and epidemiological significance of hepatitis B marker serological model in health examinees of Zhejiang province

作　　者：俞小忠[1] 朱辰[1] 张曙云[1] 董敏[1] 夏燕[1] 胡旭姣[1] 

机构地区：[1]南京军区杭州疗养院健康管理体检中心,浙江杭州310007

出　　处：《中国公共卫生》2011年第8期1027-1029,共3页Chinese Journal of Public Health

摘　　要：目的了解浙江省健康体检人群乙肝病毒标志物(HBV-M)模式分布。方法对体检人群血清检测HBV-M及丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)水平,并对结果进行统计分析。结果 21 035名体检人群HBsAg阳性率为7.21%,抗-HBs阳性率为42.05%,HBV-M阴性检出率为42.17%;HBsAg(+)抗-HBe(+)抗-HBc(+)阳性率男性组明显高于女性组,抗-HBs(+)抗-HBc(+)、抗-HBs(+)抗-HBe(+)抗-HBc(+)阳性率女性组明显高于男性组,男、女性HBsAg(+)HBeAg(+)抗-HBc(+)阳性率均随年龄增长下降,抗-HBc(+)阳性率随年龄增长升高,HBsAg阳性模式ALT、AST水平均高于HBV-M阴性模式。结论浙江省HBsAg阳性模式仍为肝功能受损较重的主要模式,抗-HBs(+)及HBV-M阴性为目前HBV-M的主要模式;对HBV-M阴性模式仍需加强乙肝疫苗接种,以预防HBV感染。Objective To study hepatitis B marker distribution model in the people receiving health examination.Methods The hepatitis B markers（HBsAg,anti-HBs,HBeAg,anti-HBe,anti-HBc） and liver function were detected in 21 035 people receiving health examination.Results The positive rate of HBsAg for positive model was 7.21%（1 517/21 035）.The positive rate of anti-HBs was 42.05% and the positive rate for hepatitis B virus-marker（HBV-M） negative model was 42.17%.The HBsAg,anti-HBc,and anti-HBe positive rates in the male were higher than those in the female（P0.01）.The anti-HBs,anti-HBc,anti-HBe,and anti-HBc positive rates in the female were significantly higher than those in the male（P0.01）.HBsAg,HBeAg and anti-HBc positive rates were decreased with age in the male and female（P0.01） and the anti-HBc positive rate was increased with the increment of age（P0.01）.The level of alanine aminotransferase（ALT） and aspartate aminotransferase（AST） in the HBsAg positive model group were higher than those in HBV-M negative model group（P0.01）.Conclusion The positive rate of HBsAg was 7.21% in health examinees in Zhejiang province and the HBsAg positive model was the major model of abnormal liver function.The ability of eliminating HBV in the female was better than that in the male.The main model of HBV-M was anti-HBs positive and HBV-M negative model.The vaccination for HBV should be promoted for the HBV-M negative model to control HBV infection.

关 键 词：乙肝标志物 丙氨酸氨基转氨酶 体检 

分 类 号：R512.62[医药卫生—内科学]