海南省甲型H1N1流感血清流行病学调查  

Serologic survey on influenza A(H1N1) 2009 in Hainan province

作　　者：曾昭长[1] 邱丽[1] 曾祥洁[1] 金玉明[1] 林春燕[1] 李臻[1] 冯芳莉[1] 

机构地区：[1]海南省疾病预防控制中心应急管理办公室,海口570203

出　　处：《中国公共卫生》2011年第8期1054-1056,共3页Chinese Journal of Public Health

摘　　要：目的了解海南省2009年甲型H1N1流感大流行高峰后期人群感染水平及流行趋势。方法于2009年12月和2010年1-3月共5次在海口市抽取医院门诊患者、血液中心志愿者,利用血凝抑制(HI)方法进行血清标本甲型H1N1流感抗体检测。结果 5次调查的人群抗体阳性率依次为10.50%(40/381)、16.06%(62/386)、31.35%(121/386)、23.16%(91/393)和38.02%(146/384),随时间推移总体呈增长趋势(χ2=81.17,P<0.05);除0～5岁组外,6～17岁、18～55岁及≥56岁组抗体阳性率均随时间推移而上升(χ2=4.22,P>0.05;χ2=21.25,P<0.05;χ2=39.05,P<0.05;χ2=26.85,P<0.05);6～17岁组抗体阳性率5次调查均最高。结论海南省甲型H1N1流感人群免疫水平逐步提高,该疾病在海南省的流行将维持在较低水平;6～17岁人群为主要感染人群。Objective To understand the infection status of influenza A（H1N1） 2009 virus and its epidemic trend in the post-peak phase of the pandemic among the population in Hainan province,2009.Methods Serum specimens were collected from outpatients in hospitals and volunteers in blood donation center between December 2009 and January to March 2010 in Haikou city,and tested with hemagglutination-inhibition（HI） assays.Rates of protective antibody against influenza A（H1N1） 2009 were estimated.Results For the five batches samples,the rates of protective antibody against influenza A（H1N1） 2009 were 10.50%,16.06%,31.35%,23.16%,and 38.02%,respectively,showing a rising tendency with time（linear-by-linear association,χ2=81.17,P 0.05）.Except the age group of 0-5 years,the antibody positive rates of 6-17,18-55,and ≥56 years age groups increased with the time（χ2=4.22,P0.05;χ2=21.25,P0.05;χ2=39.05,P0.05;χ2=26.85,P0.05）.And the age group of 6-17 years had the highest positive rate among the four age groups.Conclusion The influenza A（H1N1） 2009 epidemic reached its peak in Hainan province during October to November 2009.After the peak,the antibody level against influenza A（H1N1） 2009 increased gradually.Till March 2010,an immune barrier of population had formed initially,indicating that the epidemic might maintain at a low level for a certain period of time.People aged 6-17 years had the highest infection rate among all age groups.

关 键 词：甲型H1N1流感 血清流行病学调查 抗体 

分 类 号：R511.7[医药卫生—内科学]