环磷腺苷葡胺、1,6-二磷酸果糖联合治疗小儿毛细支气管炎合并心肌损害疗效观察  

Therapeutic Effects of Meglumine Adenosine Cyclophosphate Combined With Fructose l,6-Diphosphate on Bronchiolitis Complicated With Myocardial Damage

作　　者：薛慧敏[1] 宋德花[1] 耿长燕[1] 李文[2] 卢宪梅[2] 

机构地区：[1]山东省济南市第三人民医院,山东济南250101 [2]山东大学齐鲁医院

出　　处：《中华妇幼临床医学杂志（电子版）》2011年第1期37-39,共3页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

摘　　要：目的观察环磷腺苷葡胺(meglumine adenosine cyclophosphate,MAC)、1,6-二磷酸果糖(fructose l,6-diphosphate,FDP)联合治疗小儿毛细支气管炎合并心肌损害(bronchiolitis complicated with myocardial damage)的疗效,探讨最佳治疗方案。方法将2007年1月至2009年6月山东省济南市第三人民医院收治的毛细支气管炎合并心肌损害的235例患儿随机分为治疗组(n=115)和对照组(n=120)(本研究遵循的程序符合山东省济南市第三人民医院人体试验委员会制定的伦理学标准,得到该委员会批准,分组征得受试对象监护人的知情同意,并与其签署临床研究知情同意书)。两组患儿除采用抗感染、吸氧、解痉、平喘等常规综合治疗之外,治疗组再采用环磷腺苷葡胺、1,6-二磷酸果糖联合治疗营养心肌;对照组则加能量合剂营养心肌。观察两组主要临床症状消失时间、心肌酶谱变化。结果治疗组患儿临床症状、体征消失时间和血清心肌酶恢复时间,均明显短于对照组,差异有显著意义(P<0.01)。结论环磷腺苷葡胺、1,6-二磷酸果糖联合治疗毛细支气管炎合并心肌损害疗效明确,未见明显不良反应,但是否值得临床推广应用,尚需多中心、大样本随机对照研究证实。Objective To investigate therapeutic effects of meglumin adenosine cyclophosphate（MAC）combined with fructose l,6-diphosphate（FDP）in the treatment of bronchiolitis complicated with myocardial damage.Methods From January 2007 to June 2009,235 children who were diagnosed as bronchiolitis complicated with myocardial damage were recruited into this study.They were randomly divided into two groups,treatment group（n=115）and control group（n=120）.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Third People＇s Hospital of Jinan,Shandong Province.Informed consent was obtained from all participants.Two groups were received the routine treatment,then,treatment group were added meglumine adenosine cyclophosphate＋ fructose l,6-diphosphate,while control group were added energy mixture.The regression time of main clinical symptoms and change trend of myocardial enzymes were observed.Results The regression time of main clinical symptoms,recovery time of serum myocardial enzymes in treatment group were shorter than those of control group（P0.01）.Conclusion Therapeutic effects of meglumin adenosine cyclophosphate combined with fructose l,6-diphosphate in the treatment of bronchiolitis complicated with myocardial damage is effective with no adverse reaction.But further study should be conducted to comfirm whether it is worthy of clinical application.

关 键 词：毛细支气管炎 心肌酶 心肌损害 环磷腺苷葡胺 1 6-二磷酸果糖 

分 类 号：R725.6[医药卫生—儿科]