妊娠期肝内胆汁淤积症胎儿宫内缺氧机制的研究进展  

Research Progress of Fetus Hypoxia Mechanism of Intrahepatic Cholestasis of Pregnancy

作　　者：何毛毛[1] 王晓东[1] 

机构地区：[1]四川大学华西第二医院妇产科,四川成都610041

出　　处：《中华妇幼临床医学杂志（电子版）》2011年第1期60-63,共4页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：四川省科技支撑计划项目(2009SZ0016)~~

摘　　要：妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)是发生在妊娠中、晚期的一种妊娠特有并发症,以皮肤瘙痒、胆汁酸升高和肝功能异常为主要临床表现。此妊娠并发症孕产妇预后良好,但可导致胎儿早产、羊水胎粪污染、胎儿宫内窘迫,甚至胎死宫内等严重妊娠结局。因此,研究妊娠期肝内胆汁淤积症胎儿宫内缺氧的机制对围生儿预后至关重要。本文就妊娠期肝内胆汁淤积症胎儿宫内缺氧机制的研究进展,综述如下。Intrahepatic cholestasis of pregnancy（ICP）is a cholestatic disorder characterized by pruritus with onset in the second or third trimester of pregnancy,elevated serum aminotransferases and bile acid levels,and spontaneous relief of signs and symptoms within two to three weeks after delivery.Maternal prognosis is good,but it increases the risk of preterm delivery,meconium staining of amniotic fluid,fetal distress,and fetal death.This article reviews the mechanism of fetal hypoxia in intrahepatic cholestasis of pregnancy.

关 键 词：妊娠期肝内胆汁淤积症 胎儿宫内缺氧 

分 类 号：R714.2[医药卫生—妇产科学]