The Effectiveness of Watermelon Endocarp Extract in Inhibiting Lipase Activity Relative to the Hypolipidemic Drugs  

作　　者：Subandi Hambali Indah Langitasari 

机构地区：[1]Departement of Chemistry, State University of Malang, Malang 65145, Indonesia

出　　处：《Journal of Life Sciences》2011年第7期541-545,共5页生命科学（英文版）

摘　　要：In the effort to prove the effectiveness of watermelon endocarp extract as a hypolipidemic, the authors have done an initial experiment of lipase inhibition with the extract. The puposes of this study are to evaluate： （1） the optimum condition of lipase in the pankreoflat tablet, （2） the effect of watermelon endocarp extract in inhibition the lipase activity, and （3） the effectiveness of watermelon endocarp extract as lipase inhibitor relative to the hypolipidemic drugs （orlistat）. Watermelon endocarp was extracted by blender, squeezed and filtered. As a source of lipase has been used pankreoflat （Kimia Farina） tablet, inhibition test was performed by mixing 35 mL with substrate （olive oil） that has been coupled with one tablet （0.25 g） ofpankreoflat and extract of 50 g watermelon endocarp and then incubated at 37℃, pH 7.5 for 25 minutes. Lipase activity is indicated by the amount ofNaOH titrant which was used to neutralize the free fatty acid from hydrolysis of olive oil. The results showed that 50 g of watermelon endocarp can produce 26 mL extract and decrease the lipase activity by 70.34%, or equivalent to 85% of the effectiveness of one tablet orlistat （120 mg）, one of the hypolipidemic drugs.

关 键 词：Watermelon endocarp a lipase inhibitor orlistat. 

分 类 号：TS210.1[轻工技术与工程—粮食、油脂及植物蛋白工程] TQ463.4[轻工技术与工程—食品科学与工程]