蛋白质翻译后修饰研究进展  

Research Progress of Protein Translational Modifications

作　　者：郭会灿[1] 

机构地区：[1]石家庄职业技术学院化学工程系,石家庄050081

出　　处：《生物技术通报》2011年第7期18-21,共4页Biotechnology Bulletin

摘　　要：翻译后修饰在蛋白质加工、成熟的过程中发挥着重要的作用,它可以改变蛋白质的物理、化学性质,影响蛋白质的空间构象、立体位阻及其稳定性,进而对蛋白质的生物学活性产生作用,引起蛋白质的功能改变。修饰基团自身的结构特性对蛋白质的性质、功能也会产生深远的影响。在已有的研究基础上,综述蛋白质翻译后修饰的主要类型以及各修饰作用潜在的生物学功能。Posttranslational modifications which play an important role in the course of protein processing as well as protein maturation,could alter the physical and chemical properties of proteins.As a result,the space conformation,three-dimensional location and stability of proteins would change which may lead to the functional alteration of proteins.Also,the structure features of modified groups could produce a far-reaching impact on the properties as well as functions of proteins.Based on the existing research,we reviewed the modifying types and their potential functions during posttranslational modifications in this paper.

关 键 词：蛋白质翻译后修饰 糖基化 乙酰化 泛素化 磷酸化 

分 类 号：Q75[生物学—分子生物学]