藏木香的化学成分研究  

Study on Chemical Constituents in Roots of Inula racemosa

作　　者：张婷[1] 陈若芸[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所,中草药物质基础与资源利用教育部重点实验室,北京100050

出　　处：《中国药学杂志》2011年第15期1159-1162,共4页Chinese Pharmaceutical Journal

基　　金：国家科技重大专项(2009ZX09302-003)

摘　　要：目的研究菊科旋覆花属植物藏木香的化学成分。方法利用硅胶柱色谱、Sephadex LH-20和反相RP-18柱色谱等手段进行分离纯化,并通过波谱数据鉴定结构。结果分离鉴定了13个化合物:deactyl-γ-cycloepitulipinolide(1),5-deoxy-5-hydroper-oxytelekin(2),11,13-dihydroisoalantolactone(3),8-epi-ivangustin(4),alloalantolactone(5),clemaphnol A(6),dammara-20,24-dien-3β-OAc(7),木栓酮(Friedelin,8),反式咖啡酸乙酯(ethyl trans-3,4-dihydroxycinnamate,9),丁香酸(syringic acid,10),5-羟甲基糠醛(5-hydroxymethyl-furaldehyde,11),正丁基-β-D-吡喃果糖苷(n-Butyl-β-D-fructopyranoside,12),乙基-β-D-吡喃果糖苷(ethyl-β-D-fructopyranoside,13)。结论化合物1,2,6～13为首次从该属植物中分离,化合物3,4为首次从该植物中分离。OBJECTIVE To investigate the chemical constituents in the roots of lnula racemosa. METHODS The isolation and purification were performed by various chromatographies such as silica gel, Sephadex LH -20 and RP-C18 column chromatography and so on. RESULTS Thirteen compounds were isolated and identified as ： deactyl-γ-cycloepitulipinolide （ 1 ） ,5-deoxy-5-hydroperoxytelekin （ 2 ）, 11,13-dihydroisoalantolactone （ 3 ）, 8 -epi-ivangustin （4）, alloalantolactone （5）, clemaphnol A （ 6 ）, dammara-20,24-dien- 3 I^-OAc （7）, friedelin （ 8 ）, ethyl trans-3,4-dihydroxycinnamate （9）, syringic acid （10）, 5-hydroxymethyl-furaldehyde （ 11 ）, n-butyl-β-D-fructopyranoside （ 12）, ethyl-β-D-fructopyranoside （13）. CONCLUSION Compounds 1,2, 6 - 13 are isolated from the genus of Inula for the first time, and compounds 3 and 4 are isolated from this plant for the first time.

关 键 词：菊科 旋覆花属 藏木香 倍半萜 

分 类 号：R284[医药卫生—中药学]