异戊烯基呫吨酮类天然产物的抗肿瘤活性研究进展  

Advances in Research on Anti-tumor Activity of Natural Prenylated Xanthones

作　　者：王帆[1] 叶红春[1] 夏开国[1] 尤启冬[1] 徐嘉莹[1] 王泳鑫[1] 王进欣[1] 

机构地区：[1]中国药科大学药物化学教研室,江苏南京210009

出　　处：《药学进展》2011年第7期304-311,共8页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金(No.30873157);江苏省2008年度"青蓝工程"优秀骨干教师培养项目

摘　　要：近年来有研究显示,含有异戊烯基结构的天然呫吨酮类化合物对多种肿瘤具有显著抑制活性,故而从此类化合物中寻找具有开发价值的抗肿瘤先导化合物,已成为一个研究热点。按来源分别介绍异戊烯基呫吨酮类天然化合物及其抗肿瘤活性研究新进展,并对其中部分化合物的作用机制及构效关系进行了初步探讨。Recently, some reports have shown that the prenylated xanthones from the natural products have significant inhibitory activity against several kinds of tumors, so it has become a meaningful and potential research direction for people to discover the lead compounds from the natural prenylated xanthones which possess anti-tumor activity. The recent progress in research on the prenylated xanthones isolated from the natural products and their anti-tumor activity were introduced in this article. Moreover, the mechanisms of some compounds and the structure-activity relationships were also discussed in brief.

关 键 词：呫吨酮 异戊烯基 抗肿瘤活性 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]