离子液体[Bmim]Cl-CrCl_2促进高炔丙醇化合物的合成  

Synthesis of Homopropargyl Alcohols Promoted by [Bmim]Cl-CrCl_2 Ionic Liquid

作　　者：金德宽[1] 

机构地区：[1]江苏食品职业技术学院生物化工系,江苏淮安223003

出　　处：《化学世界》2011年第7期427-431,共5页Chemical World

基　　金：淮安市科技支撑计划项目(HAG20100044)

摘　　要：离子液体[bmim]Cl-CrCl2促进下,醛酮与炔丙基溴发生Barbier型反应合成了高炔丙醇化合物,考察了反应条件和不同底物对炔丙基化反应的影响。结果表明,在[bmim]Cl与CrCl2物质的量比为1∶2,醛酮、炔丙基溴和离子液体物质的量比为2∶3∶2,反应温度为50℃和反应时间为1~5 h的条件下,一系列醛酮能与炔丙基溴顺利进行反应,以81.4%~98.3%的收率高选择性地得到高炔丙醇。该离子液体经处理后可以重复使用。Homopropargyl alcohols were synthesized by [Bmim]Cl-CrCl2 ionic liquid-promoted Barbier-type reaction of aldehydes or ketones with 3-bromopropyne.The effects of the reaction conditions and various substrates on propargylation reactions were investigated.When the molar ratio of [Bmim]Cl to CrCl2 in ionic liquid was 1︰2,the molar ratio of aldehyde or ketone to 3-bromopropyne and ionic liquid was 2︰3︰2,reaction temperature was 50 ℃,reaction time was 1~5 h,and the ionic liquid [Bmim]Cl-CrCl2 was employed,the propargylations of various aldehydes or ketones with 3-bromopropyne to afford the corresponding homopropargyl alcohols gave 81.4%~98.3% yields and high selectivity.The ionic liquid could be reused.

关 键 词：高炔丙醇 炔丙基化 Barbier型反应 离子液体 

分 类 号：O621[理学—有机化学]