电位滴定法测定盐酸苯乙双胍含量  

Determination of Phenformin hydrochloride by potentiometric titration

作　　者：方方[1] 尹菁[1] 石蓓佳[1] 

机构地区：[1]江苏省食品药品检验所,南京210008

出　　处：《海峡药学》2011年第7期73-75,共3页Strait Pharmaceutical Journal

摘　　要：目的建立环保便捷的盐酸苯乙双胍含量的电位滴定方法。方法采用Mettler Toledo DL53电位滴定仪、Mettler DG113-GC电极。以20mL冰醋酸和20mL醋酐为溶剂进行电位滴定。结果盐酸苯乙双胍取样量在0．06～0．14g范围内。线性良好，r=0．9999（n=5），中间精密度为0．34％，稳定性试验和重复性试验的RSD均小于0．5％。结论该方法适于盐酸苯乙双胍原料的含量测定。OBJECTIVE To establish an environmental and convenient method for determination of phenformin hydrochloride.METHODS The potentiometric titration was performed on Mettler Toledo DL53 and Mettler DG113-GC using 20mL glacial acetic acid and 20mL acetic anhydride as solvent. RESULTS The linear range of weight was 0.06-0.14g（r= 0.9999, n= 5）, inter space accuracy was 0.34%, the RSD of stability experiment and repeatability experiment were less than 0.5 %. CONCLUSION This method was suitable for the determination of phenformin hydrochloride.

关 键 词：盐酸苯乙双胍 电位滴定法 含量测定 

分 类 号：R927.2[医药卫生—药学]