二氧化氯缓释凝胶促进家兔创面愈合效果的实验研究  

Experimental study on the effect of chlorine dioxide delayed release gel on the wound healing in rabbits

作　　者：金伟[1] 闫梦菲[2] 胡超云[1] 徐亚琴[1] 谢茵[1] 全红[1] 毕小平[1] 

机构地区：[1]山西医科大学药学院基础综合实验室,太原030001 [2]南京农业大学动物科技学院

出　　处：《山西医科大学学报》2011年第7期559-562,共4页Journal of Shanxi Medical University

基　　金：山西省科技攻关项目(20080311059-3)

摘　　要：目的探讨二氧化氯缓释凝胶对家兔创面愈合的作用与影响。方法采用家兔本身作为对照,通过皮肤刺激性试验和二氧化氯缓释凝胶作用效果试验,观察该制剂对家兔皮肤刺激性以及对伤口愈合的作用,记录1周内家兔创面平均愈合率,并对其进行拍照记录。结果二氧化氯缓释凝胶、生理盐水和凝胶空白基质对家兔皮肤均无刺激;1.5%甲醛溶液对家兔完整皮肤有强刺激性。涂抹二氧化氯缓释凝胶的创伤面在用药6 d后伤口平均愈合率即为100%,其效果与市售莫匹罗星软膏基本没有区别,并且止血效果显著。结论二氧化氯缓释凝胶具有快速止血、促进伤口愈合的疗效,可用于预防与治疗开放性伤口的感染,疗效满意,为患者创面感染的治疗提供一种新的合理有效的用药方案。Objective To explore the effect of chlorine dioxide delayed release gel on wound healing of rabbits. Methods The irritation of the chlorine dioxide delayed release gel to the skin was test with normal saline,the blank gel matrix and 1.5% formaldehyde solution as the controls in the same rabbits,and its effect on wound healing by skin irritation test and effect test,and the average rates of wound healing were observed in one week and the wound was photographed. Results The chlorine dioxide delayed release gel,saline and the blank gel matrix were not irritant to the skin of rabbits,but 1.5% formaldehyde solution had strong irritation to the skin of rabbits.The average rate of wound healing was 100% after smearing chlorine dioxide delayed release gel for six days,and it was not significantly different from the effect of mupirocin ointment.The effect of chlorine dioxide delayed release gel on hemostasis was conspicuous. Conclusion The chlorine dioxide delayed release gel has the advantages of rapid hemostasis and wound repair,and can be used to prevent and cure the wound infection with a satisfactory effect,which provides a reasonable and effective new drug program for the treatment of wound infection in clinics.

关 键 词：二氧化氯缓释凝胶 刺激性试验 创面愈合 

分 类 号：R969.4[医药卫生—药理学]