BMIPP的合成与^(125)I标记  

SYNTHESIS AND ^(125)I LABELLING OF r-METHYL-P-IODOPHENYL PENTADECANOIC ACID

作　　者：纪书仁[1] 吴春英[1] 陆春雄[1] 方平[1] 

机构地区：[1]江苏省原子医学研究所核医学国家重点实验室,无锡214063

出　　处：《同位素》1999年第4期217-220,221,共5页Journal of Isotopes

摘　　要：报道了由ω溴十一烷酸制备β甲基对碘苯代十五烷酸(BMIPP)的合成方法。终产物经红外、核磁共振、元素分析和质谱等方法确证。同时报道了BMIPP的125I标记方法,经TLC检测,标记率和放化纯度分别大于80%和98%。The method of the preparation of β methyl p iodophenyl pentadecanoic acid(BMIPP) is developed. The synthesis and physical properties of BMIPP are described. BMIPP is characterized by IR, 1 HNMR, elementary analysis and MS. 125 I BMIPP can be easily prepared by two methods: direct labelling and iodo exchange labelling. The lablling yield is 80% confirmed by TLC, and the radiochemical purity is higher than 98% after extaction.

关 键 词：BMIPP 心肌代谢显像剂 合成 碘标记化合物 

分 类 号：R817.42[医药卫生—影像医学与核医学] O628.51[医药卫生—放射医学]