LGDP改性人工心瓣材料抗细菌粘附的研究  

Modification of the Surface of Prosthetic Valve Material by LGDP for Protection Against Microbial Adhesion

作　　者：万昌秀[1] 段友容[1] 张尔永[2] 吴刚[1] 冉均国[1] 黄云超[2] 乐以伦[1] 

机构地区：[1]四川大学高分子材料系,无机材料系成都610065 [2]华西医科大学附属第一医院,成都610041

出　　处：《生物医学工程学杂志》1999年第4期411-414,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金!资助项目(39670717)

摘　　要：本实验是在Ｎ２ 低温等离子体技术（ＬＧＤＰ）对Ｄａｃｒｏｎ 材料表面改性的基础上进行的。用非反应性气体Ａｒ作载气，在其表面引入一些亲水基团，接枝抗细菌粘附的聚乙二醇和肝素。对改性后的材料作体外表皮葡萄球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ Ｅｐｉｄｅｒｍ ｉｄｉｓ，ＳＥ）的动态粘附实验，其抗细菌粘附的能力有较为明显的提高，与未改性材料相比，细菌粘附减少８０％ 以上。This study aimed at the surface modification of prosthetic valve materials by means of cold glow discharge plasma. Orthogonal design was adopted to select the optimal scheme by the experiments of the singular factor, such as output power, gas flow rate, treatment time etc. The PEG 200 was introducted to the surface. Grafting a layer of heparin onto the surface; coating a layer of PEG like onto the surface first, and then the grafting heparin. Comparing the adhesive amounts of staphylococcus epidermidis (SE), the adhesive curves for Dacron, which was treated by the above methods; the last one is the best.

关 键 词：低温等离子 表面改性 细菌粘附 人工心瓣 

分 类 号：R318.08[医药卫生—生物医学工程] R318.11[医药卫生—基础医学]