聚(丙基,3-羟丙基)DL-天冬酰胺的体内外降解及键合阿司匹林复合物的释放行为的研究  

Studies on Degradation of Poly (propyl, 3-hydroxypropyl) DL asparamide and Release of Conjugate Linking Aspirin in Vivo and in Vitro

作　　者：周涛[1] 王斌[2] 汤谷平 陈启琪 

机构地区：[1]宁波大学食工系,宁波315211 [2]浙江医科大学药学院,杭州310006

出　　处：《生物医学工程学杂志》1999年第4期423-428,共6页Journal of Biomedical Engineering

基　　金：国家自然科学基金

摘　　要：选用两种不同亲疏水性的聚天冬酰胺修饰材料进行体内外降解实验，研究结果表明，聚天冬酰胺材料的降解过程系酶解，材料的亲疏水性不同，则在体内的降解速度不同，同种材料在埋植部位、肾、肝中的代谢速度也不同。对两种材料的键合阿司匹林复合物的体内外释放试验表明，酶解有利于药物的释放，材料的亲脂性增加有利于药物的释放。Two polyasparamide derivants having different hydrophilicities were selected to be degraded in vivo and in vitro. The results demonstrate that the degradation process of polyasparamide is enzymatic hydrolysis. Materials with different hydrophobicities are different in degradation rate and the same material has different metabolic rates in the planting position, kidney and liver. The release results of two polymeric drugs indicate that protease is of advantage to release of drug, and hydrophobicity of material is also an advantage to the release.

关 键 词：聚天冬酰胺 阿司匹林 降解 释放 

分 类 号：R944.9[医药卫生—药剂学] R965.1[医药卫生—药学]