皱纹盘鲍性腺正丁醇萃取相化合物研究  

Studies on the compounds from n-butanol extract of gonad in Haliotis discus hannai Ino.

作　　者：刘璐璐[1] 李平林[1] 李八方[1] 

机构地区：[1]中国海洋大学食品科学与工程学院海洋生物活性物质实验室,山东青岛266003

出　　处：《中国海洋药物》2011年第4期38-41,共4页Chinese Journal of Marine Drugs

摘　　要：目的研究皱纹盘鲍性腺正丁醇萃取相的化学成分。方法利用硅胶柱色谱、Sephadex LH-20柱色谱、制备薄层层析等手段对化合物进行分离纯化;应用理化性质和波谱分析(1H NMR,13C NMR,MS)并结合文献对照,鉴定化合物的化学结构。结果与结论从皱纹盘鲍性腺的正丁醇萃取相分离并鉴定了8个单体化合物,即:焦谷氨酸甲酯,1-甲基胸腺嘧啶,2’-脱氧胸腺嘧啶核苷,尿嘧啶,2’-脱氧尿嘧啶核苷,3-Hydroxy-4-hydroxymethyl-4-butanolides,尿嘧啶核苷,3-甲基胸腺嘧啶。Objective To investigate the chemical constituents of the extract from n-butanol fraction of the abalone（Haliotis discus hannai Ino.） gonad.Methods The compounds were isolated and refined with silica column chromatography,Sephadex LH-20 column chromatography,preparative thin layer chromatography.Their chemical structures were identified by physicochemical analysis,spectroscopic analysis（1H NMR,13C NMR and MS）,and comparison with the data of literatures.Results and Conclusion Eight compounds were isolated from gonad in Haliotis discus hannai Ino.and their structures have been identified as methyl pyroglutamate,1-methyl thymine,2＇-deoxyadenosine,uracil,2＇-deoxyuridine,3-Hydroxy-4-hydroxymethyl-4-butanolides,uridine,3-methyl thymine.

关 键 词：皱纹盘鲍 性腺 核苷类 

分 类 号：Q959.212[生物学—动物学] R917[医药卫生—药物分析学]