相转移催化法合成19,19,26,26-四十四烷基四羧酸四乙酯  

Synthesis of tetraethyl 19,19,26,26-tetratetracontanetetracarboxylate by using phase transfer catalysis method

作　　者：王军[1] 王慧云[1] 刘景[1] 全先高[1] 周萧云[1] 田来进[2] 

机构地区：[1]济宁医学院基础医学与法医学院,山东日照276826 [2]曲阜师范大学化学与化工学院,山东曲阜273165

出　　处：《化学试剂》2011年第8期763-765,共3页Chemical Reagents

基　　金：山东省科技攻关项目(2009GG10002076)

摘　　要：研究了以丙二酸二乙酯、1,6-二溴己烷为原料,以十六烷基三甲基溴化铵(CTMBA)和聚乙二醇(PEG-1000)为协同相转移催化剂,在一定条件下首先合成了非离子Gemini表面活性剂中间体1,1,8,8-辛基四羧酸四乙酯,进而通过加原料溴代十八烷于1,1,8,8-辛基四羧酸四乙酯中,在相同催化剂条件下合成了标题化合物。对化合物结构进行了UV、1HNMR表征,并进一步考察了不同相转移催化剂对产率的影响。结果表明,CTMBA与PEG-1000为协同相转移催化剂效果最佳,产率可达76.35%。A non-ionic Gemini surfactant intermediate com- pound named tetraethyl 1,1,8,8-octanetetracarboxylate was synthesized by using diethyl malonate and 1,6-dibromohexane as feed stock, cetrimide （CTMBA） and polyethylene glycol （PEG-1000） as synergistic phase transfer catalyst under certain conditions. Then tetraethyl 19,19,26,26-tetratetracontanetetracarboxylate was synthesized through adding octadecyl bromide into tetraethyl 1,1,8,8-octanetetracarboxylate with the same catalyst. The structures were characterized by IR, ^1 HNMR and melting point（mp） after being separated and purified. Moreover, the influence of the different phase transfer catalyst on the product yield was studied. It was optimum to use the CTMBA and PEG-1000 as synergistic phase transfer catalyst, and the yield reached to 76.35 %.

关 键 词：相转移催化剂 非离子Gemini表面活性剂 中间体 合成 产率 

分 类 号：O623.6[理学—有机化学]