原发性高血压合并高尿酸血症患者血管内皮依赖性舒张功能变化及临床意义  

Detection of endothelium-dependent vascular relaxing function and clinical significance in essential hypertension patients with hyperuricemia

作　　者：陈辉[1] 莫新玲[1] 王要鑫[1] 唐建华[1] 李全忠[1] 

机构地区：[1]桂林医学院附属医院,广西桂林541001

出　　处：《山东医药》2011年第29期1-3,共3页Shandong Medical Journal

基　　金：桂林市科学研究与技术开发项目(20100128-7)

摘　　要：目的探讨原发性高血压(EH)合并高尿酸血症患者血管内皮依赖性舒张功能的变化及意义。方法选择EH患者30例、EH合并高尿酸血症患者60例及健康体检者30例,采用无创性高分辨超声技术检测三组休息、反应性充血、舌下含服硝酸甘油(GTN)后肱动脉内径的变化。结果 EH及EH合并高尿酸血症患者肱动脉血流介导性扩张百分比明显低于正常组(P<0.05),EH合并高尿酸血症患者下降更明显(P<0.01);舌下含服GTN后EH合并高尿酸血症组肱动脉内径变化与正常对照组比较有统计学差异(P<0.05),EH组与正常对照组之间无统计学差异。结论 EH合并高尿酸血症患者存在血管内皮依赖性舒张功能失调,高尿酸血症可加重血管内皮依赖性舒张功能的损害。Objective To detect the changes of endothelium-dependent vascular relaxing function in essential hypertension patients with hyperuricemia. Methods With high-resolution ultrasound, the diameter of brachial arteries at rest, during reactive hyperaemia and after sublingual GTN were measured in 120 subjiects, consisted of 60 cases of essential hypertension patients with hyperurieemia, 30 cases of essential hypertension and 30 cases normal control group. Results The results showed that the flow-mediatde dilatation（FMD） of brachial artery in the group of essential hypertension and essential hypertension patients with hyperuricemia significantly reduced compared with the normal control group（ P 〈 0.05 ）, especially in the essential hypertension patients with hyperuricemia（ P 〈 0.01 ）. There was no significant difference in response to GTN between the essential hypertension and the control group（ P 〉 0.05）, but there were significant differences in response to GTN beteeen the essential hypertension patients with hyperuricemia and the control groups （P 〈 0. 05）. Conclusions Hypentricemia might impair endothelium-dependent vasodilation.

关 键 词：高血压 原发性 高尿酸血症 内皮 血管 血管舒张 超声检查 

分 类 号：R544.1[医药卫生—心血管疾病]