大鼠性周期内缰核神经元电活动的变化  

CHANGES OF NEURONAL ELECTRIC ACTIVITIES OF HABENULAR IN ESTRUS CYCLE IN RATS

作　　者：黄民[1] 马丽娜[1] 王绍[1] 

机构地区：[1]白求恩医科大学生理教研室,长春130021

出　　处：《中国应用生理学杂志》1999年第4期316-318,共3页Chinese Journal of Applied Physiology

摘　　要：目的：探讨缰核与生殖神经内分泌功能的关系。方法：采用电生理学方法记录细胞外放电。结果：①本实验观察到动情前期及动情间期大鼠缰核（ｈａｂｅｎｕｌａｒ ｎｕｃｌｅｕｓ，Ｈｂ） 的神经元对阴道、宫颈刺激（ｖａｇｉｎｏｃｅｒｖｉｃａｌｓｔｉｍｕｌａｔｉｏｎ，ＶＣ刺激） 发生两种反应。一类神经元对ＶＣ 刺激发生放电频率增快或持续时间延长的反应，即ＶＣＥ 神经元，另一类神经元则对ＶＣ刺激发生放电频率降低或暂时终止的反应，即ＶＣＩ神经元。动情前期大鼠的ＶＣＥ及ＶＣＩ神经元多呈周期性放电；②本实验还发现，大鼠Ｈｂ 中对ＶＣ刺激发生反应的性相关神经元中多数为非特异性反应型神经元，即对ＶＣ刺激和夹尾等其它刺激发生兴奋或抑制反应，少数为特异反应型神经元，即只对ＶＣ 刺激发生反应。结论：①提示这两种神经元可能与神经分泌活动有关； ②特异反应型神经元的存在表明，Ｈｂ 可以接受ＶＣ刺激的传入信息，并对其发生反应。ＶＣ刺激可能通过影响Ｈｂ 神经元的活动。Aim:To investigated the related between Hb and function of reproductive neuroendocrine. Methods: By the use of extracellular recording. Results: ①There were two kinds of neurons responsed to stimulation of uterine cervix. One kind of neurons, increasing of firing frequency or duration while VC was stimulated, are called VCE neurons.Other kinds of neurons,decreasing of firing frequency or abeyance, are celled VCI neurons. VCE and VCI neurons of rats in proestrus took the form of periodic firing.② The majority of Hb neurons which response to the stimulation of VC are nonspecific responsive neurons, and they also respond to other stimulation. the minority of Hb neurons are specific which response to stimulation of VC only. Conclusion:① VCE and VCI neurons participated in neuronendocrine action. ② The stimulation of VC influenced the secretion of LHRH or gonadotropin by altering discharge of Hb.

关 键 词：缰核 雌二醇 生殖功能 单位放电 

分 类 号：R338.26[医药卫生—人体生理学] R339.2[医药卫生—基础医学]