纳络酮对离体心房肌收缩力及搏动频率的作用  

THE INOTROPIC AND CHRONOTROPIC EFFECTS OF NALOXONE ON ISOLATED ATRIA

作　　者：吕顺艳[1] 朱妙章[1] 

机构地区：[1]第四军医大学生理学教研室,西安710032

出　　处：《中国应用生理学杂志》1999年第4期335-337,共3页Chinese Journal of Applied Physiology

摘　　要：目的和方法：采用离体心房灌流模型，观察非特异性阿片受体拮抗剂纳络酮对离体心房的变时变力作用，旨在探讨纳络酮对心肌的直接作用。结果：①在１５～１２０ μｍｏｌ／Ｌ的浓度范围内，纳络酮呈剂量依赖性地降低右房的自发搏动频率，增加心房肌的收缩张力；②当α，β受体阻断或μ受体激动后，纳络酮对离体心房的作用仍然存在；③纳络酮可延长心房肌的功能性不应期。结论：纳络酮对心肌具有不依赖于中枢及交感神经系统的直接作用。Aim and Methods: To test the direct effects of naloxone (an non selective opioid antagonist) on heart, we employed the isolated atrial preparations to investigate the inotropic and chronotropic actions of naloxone. Results:①naloxone reduced the spontaneous rate and increased the contractile force in a concentration dependent manner ranging from 15 to 120μmol/L;②Neither α nor β adrenergic antagonist in dose that effectively block α and β receptor can block the action of naloxone, and the effects were not antagonized by pretreatment with morphine, either.③naloxone (120 μmol/L) could prolong the functional refractory period of atria. Conclusion: Naloxone may have direct effects on heart independent on central and sympathomedullary action. Heart may be another additional organ that respond to naloxone not through opiate antagonism.

关 键 词：纳络酮 心房 变时变力 心肌收缩 搏动频率 

分 类 号：R331.31[医药卫生—人体生理学] R971.93[医药卫生—基础医学]