α硫辛酸治疗糖尿病周围神经病变84例临床观察  

Therapeutic effect of α lipoic acid on diabetic peripheral neuropathy based on 84 cases clinical observation

作　　者：宋效成[1] 凌桂梅[2] 谢秋平[1] 

机构地区：[1]解放军第413医院内一科,浙江舟山市316000 [2]广西百色市人民医院中医科,百色市533000

出　　处：《内科》2011年第5期413-415,共3页Internal Medicine

摘　　要：目的观察α硫辛酸治疗糖尿病周围神经病变的疗效。方法选择126例糖尿病周围神经病变患者,随机分成三组,每组42例。A组给予单用甲钴胺治疗,B组给予单用α硫辛酸治疗,C组给予α硫辛酸和甲钴胺联合治疗,疗程均为2周。观察三组治疗后的临床疗效及神经传导速度(NCV)。结果治疗后三组临床疗效比较,差异有统计学意义(H=12.175,P=0.02)。B组和C组疗效优于A组(P<0.05);三组治疗后神经传导速度均显著提高,C组有效率最高,但C组和B组无统计学差异。结论α硫辛酸能有效改善糖尿病周围神经病变的症状和神经传导速度。Objective To observe the therapeutic effect of α lipoic acid on diabetic peripheral neuropathy （DPN）. Methods 126 patients with diabetic peripheral neuropathy were randomly divided into three groups （ each group 42 cases）. Group A were treated by mecobalamin, Group B were treated by αlipoic acid, Group C were treated by combination of αlipoic acid and mecobalamin. The treatment courses were 2 weeks for every group. The therapeutic effect and nerve conduction velocity（NCV） of the three groups were observed at the end of treatment. Results There were statistic differences between therapeutic effects of 3 groups after treatment（H = 12. 175,P=0.02）. The therapeutic effects of both Group B ＆ C are better than Group A（P 〈0.05）;After treatment, the nerve conduction velocity were all significantly improved and Group C is the most effective one, but there is no statistical difference between Group C ＆ B. Conclusions a lipoic acid can effectively improve the symptoms and nerve conduction velocity of DPN patients.

关 键 词：糖尿病 Α硫辛酸 周围神经病变 甲钴胺 

分 类 号：R587.2[医药卫生—内分泌]