足月妊娠引产中的欣普贝生临床应用体会  

Clinical experience of dinoprostone in labor induction of full-term pregnancy

作　　者：吕凤冰[1] 李晓荣[1] 

机构地区：[1]广东省佛山市南海区妇幼保健院妇产科,广东佛山528200

出　　处：《中国妇幼健康研究》2011年第4期550-552,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的观察欣普贝生对足月妊娠促宫颈成熟和引产的临床效果及安全性。方法采用病例对照研究的方法，按照知情同意的原则，将120例孕妇用抽签法以2：1分为试验组80例及对照组40例。试验组采用欣普贝生1枚放置于阴道后穹窿；对照组静脉点滴小剂量（5％葡萄糖注射液500mL＋催产素2．5IU）催产素，比较两组用药后的宫颈Bishop评分和宫缩、分娩的发生时间以及妊娠结局。结果试验组用药后12小时宫颈评分8．64±2．02分，明显高于对照组的5．89±1．98分（t=7．08，P〈0．01）；试验组剖宫产率低于对照组（X^2=10．55，P〈0．01）。两组间胎儿窘迫发生率（X^2=0．01，P〉0．05）、新生儿窒息率（X^2=O．38，P〉0．05）比较均无显著性差异。结论欣普贝生能够有效地促进宫颈成熟，缩短临产时间，增加阴道分娩率，可安全地用于临床。Objective To observe the clinical effect and safety of dinoprostone in cervical ripening and induction of full-term pregnancy. Methods In accordance with the principle of informed consent, a case-control study was carried out among 120 pregnant women who were divided into trial group （80 cases） and control group （40 cases） according to the ratio of 2：1 by drawing lot. In the trial group one piece of dinoprostone was put into posterior fornix and in the control group low dosage of oxytocin was given through IVD （5 % Glucose 50OraL ＋ Oxytocin 2.5IU）. The Bishop scores, uterine contraction, delivery time and pregnancy outcomes between two groups were compared. Results After drug administration the 12h Bishop score of the trial group was 8.64 ＋ 2.02, which was significantly higher than that （5.89 ± 1.98 ） in the control group （ t= 7.08, P 〈 0.01 ）. The rate of cesarean section in the trial group was lower than that in the control group （X^2 = 10.55, P 〈 0.01 ）. The differences in the incidence of fetal distress （X^2 = 0.01, P 〉 0.05 ） and neonatal asphyxia （X^2 = 0.38, P 〉 0.05） between two groups were not significant （P 〉 0.05 ）. Conclusion Dinoprostone can effectively enhance cervical ripening, shorten parturient time and increase vaginal delivery rate. It can be applied in clinics safely.

关 键 词：足月妊振 欣普贝生 宫颈成熟 引产 

分 类 号：R719.3[医药卫生—妇产科学]