用于毛细管电泳手性分离的一种新的手性选择剂——β-环糊精聚合物  

A Novel Chiral Selector in Capillary Electrophoresis—β Cyclodextrin Polymer

作　　者：麻丽媛[1] 韩江华[1] 王洪[1] 冯静 顾峻岭[1] 傅若农[1] 

机构地区：[1]北京理工大学化工与材料学院,北京100081

出　　处：《色谱》1999年第6期567-569,共3页Chinese Journal of Chromatography

基　　金：国家自然基金

摘　　要：用新合成的β－环糊精聚合物（ＥＰ－β－ＣＤ），并以天然环糊精（β－ＣＤ） 和羧甲基环糊精（ＣＭ－β－ＣＤ） 手性拆分剂作对比，选取扑尔敏、山梗菜碱、维拉帕米为测试物，优化分离条件，研究了ＥＰ－β－ＣＤ的拆分能力，并与其它两种拆分剂进行了比较。Three chiral selectors  CM β CD , EP β CD , β CD  were studied for the enatio separation of three drugs under optimum conditions respectively. The results demonstrate that the resolving power for the drugs is as follows  CM β CD > EP β CD >β CD , with the exception of lobeline. This is due to the- CH 2COOCH 3 group of  CM β CD , which will change the combination and improve the recognition on guest molecules. Although  EP β CD is inferior to CM β CD  for the separation of chlorpheniramine and verapamil, it has excellent recognition on lobeline and it has not been reported previously. In most cases  EP β CD is superior to β CD  The explanations are: (1) EP β CD  has good solubility in water, which enables high concentrations to be used and consequently achieves excellant separation of racemic compounds, (2)the polymerization of β CD  changes the properties of CD units and the process produces a more rigid and different conformation from CD, (3)we must attribute much merits to the cooperation or synergism of two, three or even more CD moieties of two polymers for inclusion. Complexation with analytes possesses more than one guest part in their structure.

关 键 词：毛细管电泳 拆分 环糊精聚合物 手性选择剂 

分 类 号：O657.803[理学—分析化学]