醋酸麦迪霉素合成工艺研究  

A TECHNOLOGICAL STUDY ON SYNTHESIS OF MIDECAMYCIN ACETATE

作　　者：傅勇坚[1] 刘小平[1] 赵红钢 

机构地区：[1]湘潭矿业学院化学工程系,湖南湘潭411201

出　　处：《湘潭矿业学院学报》1999年第4期43-46,共4页Journal of Xiangtan Mining Institute

摘　　要：对用麦迪霉素为原料直接合成醋酸麦迪霉素的工艺进行研究－ 用ＤＭＡＰ作酰化反应催化剂时，可以避免分子内异构化和过度酰化等副反应－ 考察了原料配比、反应温度、反应时间等因素对酰化产物收率的影响－ 用正交试验发现选择工艺条件为：麦迪霉素与乙酰氯的摩尔比１∶３ ．３，反应温度６０ ℃，反应时间１０ ｈ 时，酰化反应收率为９７ ．５ ％ ，经醇解后，反应总收率为８４％ － 具有良好的工业化前景－ 表３，参５－A technological process of direct synthesizing midecamycin acetate from midecamycin and acetyl chloride was studied.The intramoleacular isomerization and excessive acetylation were avoided by using 4 dimethyl amino pyridine as acetyl catalyst.The optimum technological condition was obtained with orthogonal design,and it is as follows:molar ratio of midecamycin to acetyl chloride is 1.0:3.3,reation temperature is 60 ℃,reation time is 10h.Under the optimum condition,the yield of midecamycin acetate is 84%.3tabs.5refs. A technological process of direct synthesizing midecamycin acetate from midecamycin and acetyl chloride was studied.The intramoleacular isomerization and excessive acetylation were avoided by using 4 dimethyl amino pyridine as acetyl catalyst.The optimum technological condition was obtained with orthogonal design,and it is as follows:molar ratio of midecamycin to acetyl chloride is 1.0:3.3,reation temperature is 60 ℃,reation time is 10h.Under the optimum condition,the yield of midecamycin acetate is 84%.3tabs.5refs.

关 键 词：酸酸玫迪霉素 合成 工艺 研究 麦迪霉素 

分 类 号：TQ465.5[化学工程—制药化工]